Andreas Block
Baylor College of Medicine
9 Papers
257 Citations
Andreas Block is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Suicide gene & Genetic enhancement. The author has an hindex of 7, co-authored 9 publications.
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Papers
Adenoviral-Mediated Herpes Simplex Virus Thymidine Kinase Gene Transfer : Regression of Hepatic Metastasis of Pancreatic Tumors
Andreas Block,Shu Hsia Chen,Ken-ichiro Kosai,Milton J. Finegold,Savio L. C. Woo,Savio L. C. Woo +5 more
TL;DR: Results indicate that transduction of the HSV-tk gene followed by ganciclovir is highly efficient for growth inhibition of hepatic metastases of pancreatic carcinoma.
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Adenovirus-mediated suicide gene therapy for experimental bladder cancer
Mark A. Sutton,Scott Berkman,Shu-Hsia Chen,Andreas Block,Truong D. Dang,Michael W. Kattan,Thomas M. Wheeler,David R. Rowley,Savio L. C. Woo,Seth P. Lerner +9 more
TL;DR: Adenoviral-mediated herpes simplex virus thymidine kinase gene and prodrug ganciclovir treatment provides effective therapy in experimental murine bladder cancer by significantly inhibiting tumor growth and improving host survival.
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In vivo gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration.
X W Tong,Andreas Block,Shu-Hsia Chen,Charles F. Contant,Irina U. Agoulnik,Kerstin P. Blankenburg,Raymond H. Kaufman,Savio L. C. Woo,Dirk G. Kieback +8 more
TL;DR: Adenovirus-mediated thymidine kinase gene therapy is a realistic approach to ovarian cancer treatment that warrants investigation in the clinical setting.
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Gene therapy of metastatic colon carcinoma: regression of multiple hepatic metastases by adenoviral expression of bacterial cytosine deaminase.
Andreas Block,Christian T.F. Freund,Shu Hsia Chen,Khiem Pham Nguyen,Milton J. Finegold,Eberhard Windler,Savio L. C. Woo +6 more
TL;DR: Suicide gene therapy using CD may be promising as an adjuvant treatment regimen for hepatic micrometastases of human colon carcinoma.
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•Journal Article
Adenovirus-mediated thymidine kinase gene transduction in human epithelial ovarian cancer cell lines followed by exposure to ganciclovir
TL;DR: Cell killing efficacy and toxicity of adenovirus-mediated transfer of the HSV-TK gene followed by administration of ganciclovir were studied in two human epithelial ovarian cancer cell lines and ADV/RSV- TK mediated gene therapy may be a promising approach in ovarian cancer.
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