Andrea Thiel
Saarland University
7 Papers
Andrea Thiel is an academic researcher from Saarland University. The author has contributed to research in topics: Vitamin D and neurology & Amyloid precursor protein. The author has an hindex of 4, co-authored 5 publications.
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Papers
Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.
Marcus O. W. Grimm,Andrea Thiel,Anna A. Lauer,Jakob Winkler,Johannes Lehmann,Liesa Regner,Christopher Nelke,Daniel Janitschke,Céline Benoist,Olga Streidenberger,Hannah Stötzel,Kristina Endres,Christian Herr,Christoph Beisswenger,Heike S. Grimm,Robert Bals,Frank Lammert,Tobias Hartmann +17 more
TL;DR: Vitamin D and analogues decreased β-secretase activity, not only in mouse brains with mild vitamin D hypovitaminosis, but also in non-deficient mouse brains, suggesting that supplementation of vitamin D or vitamin D analogues might have beneficial effects in AD prevention.
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Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells.
Daniel Janitschke,Christopher Nelke,Anna A. Lauer,Liesa Regner,Jakob Winkler,Andrea Thiel,Heike S. Grimm,Tobias Hartmann,Marcus Otto Walter Grimm +8 more
- 02 Nov 2019
TL;DR: All MTXs act via the pleiotropic mechanism resulting in decreased Aβ and show beneficial properties with respect to AD in neuroblastoma cells, suggesting thatMTXs should be integrated in a healthy diet rather than be used exclusively to treat or prevent AD.
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Profiling of Alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis.
Marcus O. W. Grimm,Anna A. Lauer,Sven Grösgen,Andrea Thiel,Johannes Lehmann,Jakob Winkler,Daniel Janitschke,Christian Herr,Christoph Beisswenger,Robert Bals,Heike S. Grimm,Tobias Hartmann +11 more
TL;DR: The results tighten the link of vitamin D and AD and underline that vitamin D influences several genes also in brain, highlighting that a strong link not only to AD but also to other neurodegenerative diseases might exist.
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Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease.
Anna A. Lauer,Janine Mett,Daniel Janitschke,Andrea Thiel,Christoph P Stahlmann,Cornel M Bachmann,Felix Ritzmann,Bianca Schrul,Ulrike Müller,Reuven Stein,Matthias Riemenschneider,Heike S. Grimm,Tobias Hartmann,Marcus O. W. Grimm +13 more
TL;DR: In vivo, IDE expression was decreased in mouse brains devoid of APP or AICD, which was in line with a significant correlation of APP expression level and IDE expression in human postmortem AD brains, showing a tight link between A β‐production and Aβ‐degradation forming a regulatory cycle.
10
Vitamin D and Its Analogues: From Differences in Molecular Mechanisms to Potential Benefits of Adapted Use in the Treatment of Alzheimer’s Disease
Andrea Thiel,Anna A. Lauer,Jörg Reichrath,Tobias Erhardt,Tobias Hartmann,Marcus O. W. Grimm,Heike S. Grimm +6 more
TL;DR: In this article , a review of the potential effects of various vitamin D analogues on comorbidities common in the context of geriatric diseases is presented. And the authors emphasize the importance of an adequate vitamin D supply and discuss the specifics of administering various analogues compared with vitamin D in patients suffering from Alzheimer's disease.