Andrea Debus
University of Erlangen-Nuremberg
11 Papers
91 Citations
Andrea Debus is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Cutaneous leishmaniasis & Leishmania major. The author has an hindex of 6, co-authored 9 publications.
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Papers
TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection
Ulrike Schleicher,Katrin Paduch,Andrea Debus,Stephanie Obermeyer,Till König,Jessica C. Kling,Eliana Ribechini,Diana Dudziak,Dimitrios Mougiakakos,Peter J. Murray,Renato Ostuni,Heinrich Körner,Christian Bogdan +12 more
TL;DR: It is found that TNF antagonized alternative activation of macrophages and dendritic cells by IL-4, and deletion or TNF-mediated restriction of Arg1 unleashes the production of NO by NOS2, which is critical for pathogen control.
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High levels of susceptibility and T helper 2 response in MyD88-deficient mice infected with Leishmania major are interleukin-4 dependent.
TL;DR: MyD88 knockout mice showed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice and did not develop ulcerating lesions despite a lack of interleukin-12 (IL-12) production and a predominant T helper 2 cell response.
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Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1.
TL;DR: It is concluded that Arg1 expression by hematopoietic and endothelial cells is completely dispensable for clinical resolution of cutaneous leishmaniasis and for long-term persistence of L. major.
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Eosinophils, but Not Type 2 Innate Lymphoid Cells, Are the Predominant Source of Interleukin 4 during the Innate Phase of Leishmania major Infection
Carolin Sasse,David Barinberg,Stephanie Obermeyer,Andrea Debus,Ulrike Schleicher,Christian Bogdan +5 more
TL;DR: It is concluded that eosinophils, but not ILC2, are a major innate source of IL-4 at the skin site of L. major infection.
Experimental Cutaneous Leishmaniasis: Mouse Models for Resolution of Inflammation Versus Chronicity of Disease.
Christian Bogdan,Andrea Debus,Heidi Sebald,Baplu Rai,Johanna Schäfer,Stephanie Obermeyer,Ulrike Schleicher +6 more
TL;DR: Detailed protocols for the culture, propagation, and inoculation of Leishmania promastigotes are presented, the monitoring of the course of cutaneous infection, the determination of the tissue parasite burden and the phenotyping of the ensuing immune response are presented.
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