Andrea Bottoni
University of Bologna
29 Papers
102 Citations
Andrea Bottoni is an academic researcher from University of Bologna. The author has contributed to research in topics: Catalysis & Enantioselective synthesis. The author has an hindex of 14, co-authored 29 publications. Previous affiliations of Andrea Bottoni include École Normale Supérieure & University of Valencia.
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Papers
Graphene can wreak havoc with cell membranes.
TL;DR: Molecular dynamics shows that small hydrophobic graphene sheets pierce through the phospholipid membrane and navigate the double layer, intermediate size sheet pierce the membrane only if a suitable geometric orientation is met, and larger sheets lie mainly flat on the top of the bilayer where they wreak havoc with the membrane and create a patch of upturnedospholipids.
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Mechanistic Insights into Enantioselective Gold-Catalyzed Allylation of Indoles with Alcohols: The Counterion Effect
TL;DR: The pivotal role played by the gold counterion, in terms of molecular arrangement and proton-shuttling in restoring the catalytic species, is finally documented.
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Product formation in rhodopsin by fast hydrogen motions
TL;DR: The calculations uncover the motions responsible for photoproduct formation and elucidate the reasons behind the efficient photoisomerization in the primary event of visual transduction.
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C60@Lysozyme: direct observation by nuclear magnetic resonance of a 1:1 fullerene protein adduct.
Matteo Calvaresi,Fabio Arnesano,Sara Bonacchi,Andrea Bottoni,Vincenza Calò,Stefano Conte,Giuseppe Falini,Simona Fermani,Maurizio Losacco,Marco Montalti,Giovanni Natile,Luca Prodi,Francesca Sparla,Francesco Zerbetto +13 more
TL;DR: Using Lysozyme and C60 as model systems and NMR chemical shift perturbation analysis, a protein-CNP binding pocket is identified unambiguously in solution and the effect of the binding, at the level of the single amino acid, is characterized by a variety of experimental and computational approaches.
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Gold(I)‐Catalyzed Dearomative [2+2]‐Cycloaddition of Indoles with Activated Allenes: A Combined Experimental–Computational Study
Riccardo Ocello,Assunta De Nisi,Minqiang Jia,Qing-Qing Yang,Magda Monari,Pietro Giacinto,Andrea Bottoni,Gian Pietro Miscione,Gian Pietro Miscione,Marco Bandini +9 more
TL;DR: The computational (DFT) investigation has fully elucidated the reaction mechanism providing clear evidence for a two-step reaction, and two parallel reaction pathways explain the regioisomeric products obtained under kinetic and thermodynamic conditions.
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