Andre Sachse
8 Papers
49 Citations
Andre Sachse is an academic researcher. The author has contributed to research in topics: Bone mineral & Osteoid. The author has an hindex of 5, co-authored 8 publications.
Chat about Author
Papers
Enhanced bone formation in sheep vertebral bodies after minimally invasive treatment with a novel, PLGA fiber-reinforced brushite cement.
Stefan Maenz,Olaf Brinkmann,Elke Kunisch,Victoria Horbert,Francesca Gunnella,Sabine Bischoff,Harald Schubert,Andre Sachse,Long Xin,Jens Günster,Bernhard Illerhaus,Klaus D. Jandt,Jörg Bossert,Raimund W. Kinne,Matthias Bungartz +14 more
TL;DR: The PLGA fiber-reinforced CPC is highly biocompatible and its PLGA Fiber component enhanced bone formation and improves the mechanical properties of brittle CPC, with potential applicability in load-bearing areas.
29
Low-dose BMP-2 is sufficient to enhance the bone formation induced by an injectable, PLGA fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia.
Francesca Gunnella,Elke Kunisch,Matthias Bungartz,Stefan Maenz,Victoria Horbert,Long Xin,Joerg Mika,Juliane Borowski,Sabine Bischoff,Harald Schubert,Peter Hortschansky,Andre Sachse,Bernhard Illerhaus,Jens Günster,Jörg Bossert,Klaus D. Jandt,Frank Plöger,Raimund W. Kinne,Olaf Brinkmann +18 more
TL;DR: BMP-2 significantly enhanced the bone formation induced by a PLGA fiber-reinforced CPC in sheep lumbar osteopenia, and may represent an alternative to the bioinert, supraphysiologically stiff polymethylmethacrylate cement presently used to treat osteoporotic vertebral fractures by vertebroplasty/kyphoplasty.
23
First-time systematic postoperative clinical assessment of a minimally invasive approach for lumbar ventrolateral vertebroplasty in the large animal model sheep.
Matthias Bungartz,Stefan Maenz,Elke Kunisch,Victoria Horbert,Long Xin,Francesca Gunnella,Joerg Mika,Juliane Borowski,Sabine Bischoff,Harald Schubert,Andre Sachse,Bernhard Illerhaus,Jens Günster,Jörg Bossert,Klaus D. Jandt,Raimund W. Kinne,Olaf Brinkmann +16 more
TL;DR: This first-time systematic clinical assessment of a minimally invasive, ventrolateral, lumbar vertebroplasty model in aged, osteopenic sheep resulted in short operation times, rapid postoperative recovery, and high experimental reproducibility.
20
GDF5 significantly augments the bone formation induced by an injectable, PLGA fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia
Matthias Bungartz,Elke Kunisch,Stefan Maenz,Victoria Horbert,Long Xin,Francesca Gunnella,Joerg Mika,Juliane Borowski,Sabine Bischoff,Harald Schubert,Andre Sachse,Bernhard Illerhaus,Jens Günster,Jörg Bossert,Klaus D. Jandt,Frank Plöger,Raimund W. Kinne,Olaf Brinkmann +17 more
TL;DR: GDF5 significantly enhanced the bone formation induced by a PLGA fiber-reinforced CPC in sheep lumbar osteopenia, and may qualify as an alternative to the bioinert, supraphysiologically stiff poly(methyl methacrylate) cement currently applied for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures.
15
The GDF5 mutant BB-1 enhances the bone formation induced by an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia.
Francesca Gunnella,Elke Kunisch,Stefan Maenz,Victoria Horbert,Long Xin,Joerg Mika,Juliane Borowski,Sabine Bischoff,Harald Schubert,Andre Sachse,Bernhard Illerhaus,Jens Günster,Jörg Bossert,Klaus D. Jandt,Frank Plöger,Raimund W. Kinne,Olaf Brinkmann,Matthias Bungartz +17 more
TL;DR: BB-1 significantly enhanced the bone formation induced by a PLGA fiber-reinforced CPC in sheep lumbar osteopenia, and may represent an alternative to the bioinert, supraphysiologically stiff polymethylmethacrylate cement presently used to treat osteoporotic vertebral fractures.
14