André Picard
French Institute of Health and Medical Research
32 Papers
799 Citations
André Picard is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Maturation promoting factor & Microinjection. The author has an hindex of 22, co-authored 32 publications.
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Papers
MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle
TL;DR: Sustained activity of MAPK during part of the first mitotic cell cycle is not responsible for late entry of fertilized eggs into first mitosis, and it appears that MAPK functions in meiotic maturation by preventing unfertilized eggs from proceeding into parthenogenetic development.
Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase.
TL;DR: Results show that the MPF amplification loop is controlled, both positively and negatively, by cdc2 kinase and type 2A phosphatase, respectively.
Inositol 1,4,5-triphosphate microinjection triggers activation, but not meiotic maturation in amphibian and starfish oocytes
TL;DR: Although meiotic maturation was induced in both animals by specific hormones which have been previously shown to release Ca2+ within cytoplasm, InsP3 microinjection into prophasearrested oocytes did not release them from prophase block.
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Changes in the Activity of the Maturation‐Promoting Factor Are Correlated with Those of a Major Cyclic AMP and Calcium‐Independent Protein Kinase During the First Mitotic Cell Cycles in the Early Starfish Embryo
André Picard,Jean-Claude Labbé,Gerard Peaucellier,Françoise Le Bouffant,Christian Le Peuch,Marcel Dorée +5 more
TL;DR: Cyclic variations of MPF activity have been correlated in vivo with changes in the extent of protein phosphorylation or in vitro with changes of a major protein kinase during the first cell cycles of fertilized starfish eggs.
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Release of mature starfish oocytes from interphase arrest by microinjection of human centrosomes.
TL;DR: It is reported here that microinjection of purified human centrosomes into mature starfish oocytes is sufficient to release them from arrest at interphase and to support many cleavages leading to the occasional formation of normal embryos.
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