André Nieoullon
Centre national de la recherche scientifique
137 Papers
2.7K Citations
André Nieoullon is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Dopaminergic & Striatum. The author has an hindex of 40, co-authored 137 publications. Previous affiliations of André Nieoullon include Aix-Marseille University & University of the Mediterranean.
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Papers
Regulation of dopamine levels in intrastriatal grafts of fetal mesencephalic cell suspension: an in vivo voltammetric approach
TL;DR: In the grafted rats, neurons belonging to the host population, such as the striatal cells bearing D1 receptors or the corticostriatal afferents presumed to contain glutamate, might modulate the DA levels, as was found to occur under normal conditions.
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Alzheimer's disease: neurobiological advances supporting proposals for new therapeutical approaches
TL;DR: Research projects should be aimed specifically at reducing brain lesions resulting from the disease, especially those due to the amyloid peptide accumulation, and at reducing or even halting the clinical evolution of the disease and consequent neurodegenerative processes.
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Contribution to the Study of Nigrostriatal Dopaminergic Neuron Activity Using Electrochemical Detection of Dopamine Release in the Striatum of Freely Moving Animals
TL;DR: Electrochemical methods, based on utilization of the oxidative properties of neuroactive molecules in the brain, are now being widely used for measuring the monoamines DA and serotonin and their respective metabolites, dihydroxyphenyl acetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindol acetic Acid (5HIAA).
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Further contribution to the study of corticostriatal glutamatergic and nigrostriatal dopaminergic interactions within the striatal network: an in vivo voltammetric investigation.
TL;DR: In vivo voltammetry was used in freely moving rats to study the processes whereby striatal dopamine release is regulated by corticostriatal glutamatergic neurons, and electrical stimulation of the cerebral cortex was found to markedly increase the striatal DA-related voltammetric signal amplitude.
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Quantitative behavioral study of the acute and long-term effects of two-stage bilateral 6-OHDA-induced lesions of the nigrostriatal dopaminergic system in monkeys
TL;DR: Analysis of the task performance showed that the latency to initiate the movement was permanently prolonged in monkeys showing 90% or more striatal dopamine depletion, whereas animals with less severe depletion completely recovered the taskperformance.
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