Andre Ndi
University of Buea
2 Papers
Andre Ndi is an academic researcher from University of Buea. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 2, co-authored 2 publications.
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Papers
Reappraisal of known malaria resistance loci in a large multicenter study.
Kirk A. Rockett,Geraldine M. Clarke,Kathryn Fitzpatrick,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Rachel Craik,M Jallow,David J. Conway,Kalifa Bojang,Margaret Pinder,Stanley Usen,Fatoumatta Sisay-Joof,Giorgio Sirugo,Ousmane Touré,Mahamadou A. Thera,Salimata Konate,Sibiry Sissoko,Amadou Niangaly,Belco Poudiougou,Valentina D. Mangano,Edith C. Bougouma,Sodiomon B. Sirima,David Modiano,L. Amenga-Etego,Anita Ghansah,Kwadwo A. Koram,Michael D. Wilson,Anthony Enimil,Jennifer R Evans,Olukemi K. Amodu,Subulade A. Olaniyan,Tobias O. Apinjoh,Regina N. Mugri,Andre Ndi,Carolyne M. Ndila,Sophie Uyoga,Alexander Macharia,Norbert Peshu,Thomas N. Williams,Alphaxard Manjurano,Eleanor M. Riley,Chris Drakeley,Hugh Reyburn,Vysaul Nyirongo,David Kachala,Malcolm E. Molyneux,Sarah J. Dunstan,Nguyen Hoan Phu,Nguyen Ngoc Quyen,Cao Quang Thai,Tran Tinh Hien,Laurens Manning,Moses Laman,Peter Siba,Harin Karunajeewa,Steve Allen,Angela Allen,Timothy M. E. Davis,Pascal Michon,Ivo Mueller,Angie Green,Síle F. Molloy,Kimberly J. Johnson,Angeliki Kerasidou,Victoria Cornelius,Lee Hart,Aaron Vanderwal,Miguel A. Sanjoaquin,Gavin Band,Si Quang Le,Matti Pirinen,Nuno Sepúlveda,Chris C. A. Spencer,Taane G. Clark,Tsiri Agbenyega,Eric A. Achidi,Ogobara K. Doumbo,Jeremy Farrar,Kevin Marsh,Terrie E. Taylor,Dominic P. Kwiatkowski +81 more
TL;DR: The finding that G6PD deficiency has opposing effects on different fatal complications of P. falciparum infection indicates that the evolutionary origins of this common human genetic disorder are more complex than previously supposed.
Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.
Geraldine M. Clarke,Geraldine M. Clarke,Kirk A. Rockett,Kirk A. Rockett,Kirk A. Rockett,Katja Kivinen,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Muminatou Jallow,David J. Conway,David J. Conway,Kalifa Bojang,Margaret Pinder,Stanley Usen,Fatoumatta Sisay-Joof,Giorgio Sirugo,Ousmane Touré,Mahamadou A. Thera,Salimata Konate,Sibiry Sissoko,Amadou Niangaly,Belco Poudiougou,Valentina D. Mangano,Edith C. Bougouma,Sodiomon B. Sirima,David Modiano,Lucas Amenga-Etego,Anita Ghansah,Kwadwo A. Koram,Michael D. Wilson,Anthony Enimil,Jennifer Evans,Olukemi K. Amodu,Subulade A. Olaniyan,Tobias O. Apinjoh,Regina N. Mugri,Andre Ndi,Carolyne M. Ndila,Sophie Uyoga,Alexander Macharia,Norbert Peshu,Thomas N. Williams,Thomas N. Williams,Alphaxard Manjurano,Alphaxard Manjurano,Nuno Sepúlveda,Taane G. Clark,Eleanor M. Riley,Chris Drakeley,Chris Drakeley,Hugh Reyburn,Hugh Reyburn,Vysaul Nyirongo,David Kachala,Malcolm E. Molyneux,Malcolm E. Molyneux,Sarah J. Dunstan,Nguyen Hoan Phu,Nguyen Ngoc Quyen,Cao Quang Thai,Tran Tinh Hien,Tran Tinh Hien,Laurens Manning,Moses Laman,Peter Siba,Harin Karunajeewa,Steve Allen,Angela Allen,Timothy M. E. Davis,Pascal Michon,Pascal Michon,Ivo Mueller,Ivo Mueller,Síle F. Molloy,Susana Campino,Angeliki Kerasidou,Angeliki Kerasidou,Victoria Cornelius,Victoria Cornelius,Lee Hart,Shivang S. Shah,Shivang S. Shah,Gavin Band,Gavin Band,Chris C. A. Spencer,Tsiri Agbenyega,Eric A. Achidi,Ogobara K. Doumbo,Jeremy Farrar,Kevin Marsh,Terrie E. Taylor,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +94 more
TL;DR: Aggregated across all genotypes, it is found that increasing levels of G6PD deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia, indicating that an evolutionary trade-off between different clinical outcomes of P. falciparum infection could have been a major cause of the high levels ofG6PD polymorphism seen in human populations.