Andre Mu

TL;DR: Glycolysis and the generation of mitochondrial reactive oxygen species were sufficient to induce necroptosis, a caspase-independent mechanism of host cell death that failed to eradicate S. aureus and instead promoted ΔhemB SCV pathogenicity.

TL;DR: In this paper , the authors combined in situ metabolic imaging and transcriptional analyses to demonstrate that Kp ST258 activates host glutaminolysis and fatty acid oxidation, which creates an oxidant-rich microenvironment conducive to the accumulation of anti-inflammatory myeloid cells.

TL;DR: In this paper, a single patient with Staphylococcus aureus device infection showed a largely unchanged microbiota profile during 4 weeks of phage therapy when added to systemic antibiotics.

TL;DR: In this article , the authors developed a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes.