Host Systems for the Production of Recombinant Spider Silk.

Without the sustained provision of adequate levels of oxygen by the cardiovascular system, the tissues of higher animals are incapable of maintaining normal metabolic activity, and hence cannot survive. The consequence of this evolutionarily suboptimal design is that humans are dependent on cardiovascular perfusion, and therefore highly susceptible to alterations in its normal function. However, hope may be at hand. "Photosynthetic strategies," based on the recognition that photosynthesis is the source of all oxygen, offer a revolutionary and promising solution to pathologies related to tissue hypoxia. These approaches, which have been under development over the past 20 years, seek to harness photosynthetic microorganisms as a local and controllable source of oxygen to circumvent the need for blood perfusion to sustain tissue survival. To date, their applications extend from the in vitro creation of artificial human tissues to the photosynthetic maintenance of oxygen-deprived organs both in vivo and ex vivo, while their potential use in other medical approaches has just begun to be explored. This review provides an overview of the state of the art of photosynthetic technologies and its innovative applications, as well as an expert assessment of the major challenges and how they can be addressed.

/pdf/photosymbiosis-for-biomedical-applications-3kfvu52qj2.pdf

Photosymbiosis for Biomedical Applications.

Use of photosynthetic transgenic cyanobacteria to promote lymphangiogenesis in scaffolds for dermal regeneration.

Microalgae and cyanobacteria are photosynthetic microorganisms that can be used to bioremediate anthropogenic pollutants from air, water and soil. These organisms can remediate several anthropogenic pollutants, such as carbon dioxide, nitrates and phosphates, heavy metals, pharmaceuticals, pesticides and persistent organic pollutants. The biomass generated in this process can be used as a feedstock source for the production of a multitude of valuable biobased products and applications. Polymers, resins, binders, lubricants, and coatings are some of the promising examples. This chapter provides an overview of the entire process: bioremediation using microalgae and production of value-added products, based on a biorefinery concept, focusing on circular economy and sustainability. Essential aspects of legislation and regulations are also approached. 

Bioremediation Using Microalgae and Cyanobacteria and Biomass Valorisation

Since Research Ideas and Outcomes was launched in late 2015, it has stimulated experimentation around the publication of and engagement with research processes, especially those with a strong open science component. Here, we zoom in on the first 300 RIO articles that have been published and elucidate how they relate to the different stages and variants of the research cycle, how they help address societal challenges and what forms of engagement have evolved around these resources, most of which have a nature and scope that would prevent them from entering the scholarly record via more traditional journals. Building on these observations, we describe some changes we recently introduced in the policies and peer review process at RIO to further facilitate engagement with the research process, including the establishment of an article collections feature that allows us to bring together research ideas and outcomes from within one research cycle or across multiple ones, irrespective of where they have been published. ‡ §,| ¶ ¶ ¶ © Mietchen D et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

https://riojournal.com/article/68595/download/pdf/

Open science in practice: 300 published research ideas and outcomes illustrate how RIO Journal facilitates engagement with the research process

‡ University of São Paulo, Faculty of Pharmaceutical Sciences, Department of Biochemical and Pharmaceutical Technology, São Paulo, Brazil § University of São Paulo, São Paulo, Brazil | University of São Paulo, Faculty of Pharmaceutical Sciences, Department of Department of Clinical and Toxicological Analyses, São Paulo, Brazil ¶ Federal University of São Paulo, São Paulo, Brazil # University of California, San Diego. Food and Fuel for the 21st Department, San Diego, United States of America

https://riojournal.com/article/9342/download/pdf/

Chimeric spider silk production in microalgae: a modular bionanomaterial

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Chimeric spider silk production in microalgae: a modular bionanomaterial