André Maicher
Tel Aviv University
8 Papers
22 Citations
André Maicher is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Telomere & Telomerase. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of André Maicher include German Cancer Research Center & Heidelberg University.
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Papers
Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence
Bettina Balk,André Maicher,Martina Dees,Julia Klermund,Sarah Luke-Glaser,Katharina Bender,Brian Luke +6 more
TL;DR: It is shown that RNA-DNA hybrids form at telomeres and are removed by RNase H enzymes in the budding yeast, Saccharomyces cerevisiae, and regulation of TERRA transcription and telomeric RNA- DNA–hybrid formation are important determinants of both telomere-length dynamics and proliferative potential after the inactivation of telomerase.
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Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast.
Alexandra M Poos,André Maicher,Anna K. Dieckmann,Marcus Oswald,Roland Eils,Martin Kupiec,Brian Luke,Rainer König,Rainer König +8 more
TL;DR: The results point to the transcription factors Sum1, Hst1 and Srb2 as being important for the regulation of EST1 transcription, and the machine learning method leading to a user friendly package for R which can straightforwardly be applied to similar problems integrating gene regulator binding information and expression profiles of samples of e.g. different phenotypes, diseases or treatments.
Rnr1's role in telomere elongation cannot be replaced by Rnr3: a role beyond dNTPs?
André Maicher,Martin Kupiec +1 more
TL;DR: The data indicate that telomerase may act in two different modes, one that is capable of coping with the “end-replication problem” and is functional even in the absence of RNR1 and another required for the sustained elongation of short telomeres, which fully depends on the presence of Rnr1.
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Telomeres and disease: enter TERRA.
TL;DR: The general principles behind telomere dysfunction-associated diseases are outlined and how the understanding, and eventual manipulation, of TERRA transcription could potentially be used in terms of therapeutic strategies are speculated.
Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres
André Maicher,Inbal Gazy,Sushma Sharma,Lisette Marjavaara,Gilad Grinberg,Keren Shemesh,Andrei Chabes,Martin Kupiec +7 more
TL;DR: It is suggested that telomerase has a "basal activity" mode that is sufficient to compensate for the “end-replication-problem” and does not require the presence of Rnr1 and a different "sustained activity” mode necessary for the elongation of short telomeres.