André Eichert
Free University of Berlin
12 Papers
31 Citations
André Eichert is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Transfer RNA & Nucleic acid. The author has an hindex of 4, co-authored 12 publications.
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Papers
The crystal structure of an ‘All Locked’ nucleic acid duplex
André Eichert,Katja Behling,Christian Betzel,Volker A. Erdmann,Jens P. Fürste,Charlotte Förster +5 more
TL;DR: A notable decrease of several local and overall helical parameters like twist, roll and propeller twist influence the structure of the LNA helix and result in a widening of the major groove, a decrease in helical winding and an enlarged helical pitch.
The 1.2A crystal structure of an E. coli tRNASer)acceptor stem microhelix reveals two magnesium binding sites.
André Eichert,Jens P. Fürste,Angela Schreiber,Markus Perbandt,Christian Betzel,Volker A. Erdmann,Charlotte Förster +6 more
TL;DR: The structure of an Escherichia coli tRNAs acceptor stem microhelix was solved by high resolution X-ray structure analysis and two magnesium binding sites were detected in the tRNA(Ser) aminoacyl stem.
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Crystallization and preliminary X-ray diffraction data of an LNA 7-mer duplex derived from a ricin aptamer.
Charlotte Förster,Dominik Oberthuer,Jiang Gao,André Eichert,Frederick G. Quast,Christian Betzel,Andreas Nitsche,Volker A. Erdmann,Jens P. Fürste +8 more
TL;DR: The terminal helix has been constructed as an ;all-locked' LNA and was successfully crystallized in order to investigate its structural properties and for future stabilization of the aptamer, which showed high affinity in ricin binding.
Features of "All LNA" Duplexes Showing a New Type of Nucleic Acid Geometry.
Charlotte Förster,André Eichert,Dominik Oberthür,Christian Betzel,Reinhard Geßner,Andreas Nitsche,Jens P. Fürste +6 more
TL;DR: The LNA duplex structure can no longer be described as a canonical A-type RNA geometry but can rather be brought into proximity to other backbone-modified nucleic acids, like glycol nuclei acids or peptide nucleic amino acids, which provides structural and functional features that may be successfully exploited for future application in biotechnology and drug discovery.
X-ray diffraction analysis of a human tRNAGly acceptor-stem microhelix isoacceptor at 1.18 Å resolution
André Eichert,Markus Perbandt,Angela Schreiber,Jens P. Fürste,Christian Betzel,Volker A. Erdmann,Charlotte Förster +6 more
TL;DR: Predominant differences in the structures of glycyl-tRNA synthetases and in the tRNA identity elements between prokaryotes and eukaryotes point to divergence during the evolutionary process.