Anabel José
University of Barcelona
11 Papers
71 Citations
Anabel José is an academic researcher from University of Barcelona. The author has contributed to research in topics: Pancreatic cancer & Oncolytic virus. The author has an hindex of 8, co-authored 11 publications.
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Papers
Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand
Sylvia F. Boj,Johan H. van Es,Meritxell Huch,Vivian S. W. Li,Anabel José,Pantelis Hatzis,Michal Mokry,Andrea Haegebarth,Maaike van den Born,Pierre Chambon,Peter J. Voshol,Yuval Dor,Edwin Cuppen,Cristina Fillat,Hans Clevers +14 more
TL;DR: It is shown that removal of TCF4 from β cells does not affect their function, whereas manipulating TCF3 levels in the liver has major effects on metabolism, implying that TCF 4 directly activates metabolic genes and that inhibition of Wnt signaling may be beneficial in metabolic disease.
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Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
TL;DR: IRE treatment exhibited significant antitumor effects and prolonged survival in mice with orthotopic xenografts, suggesting that IRE could be an effective treatment for locally advanced pancreatic tumors.
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Intraductal Delivery of Adenoviruses Targets Pancreatic Tumors in Transgenic Ela-myc Mice and Orthotopic Xenografts
Anabel José,Luciano Sobrevals,Juan Miguel Camacho-Sánchez,Meritxell Huch,Nuria Andreu,Eduard Ayuso,Pilar Navarro,Ramon Alemany,Cristina Fillat +8 more
TL;DR: The data show that cytotoxic adenoviruses retrogradelly injected to the pancreas can be a feasible approach to treat localized pancreatic tumors.
Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo
Judit Pujal,Meritxell Huch,Anabel José,Ibane Abasolo,Annie Rodolosse,Alba Duch,Luis Sánchez-Palazón,Frances J.D. Smith,W.H. Irwin McLean,Cristina Fillat,Francisco X. Real +10 more
TL;DR: The krt7 promoter is useful to target pancreatic ductal adenocarcinoma cells in vitro and in vivo.
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Pancreatic Cancer Gene Therapy: From Molecular Targets to Delivery Systems
Cristina Fillat,Anabel José,Xavier Bofill-Deros,Ana Mato-Berciano,Maria Victoria Maliandi,Luciano Sobrevals +5 more
TL;DR: In the current review, a detailed analysis of the different targets, the delivery vectors, the preclinical approaches and a descriptive update on the conducted clinical trials are presented.
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