Ana Vujic
Harvard University
27 Papers
97 Citations
Ana Vujic is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & DNA methylation. The author has an hindex of 12, co-authored 19 publications. Previous affiliations of Ana Vujic include Brigham and Women's Hospital & Linköping University.
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Papers
Distinct Epigenomic Features in End-Stage Failing Human Hearts
Mehregan Movassagh,Mun-Kit Choy,David A. Knowles,Lina Cordeddu,Syed Haider,Thomas A. Down,Lee Siggens,Ana Vujic,Ilenia Simeoni,Christopher J. Penkett,Martin Goddard,Pietro Liò,Martin R. Bennett,Roger Foo +13 more
TL;DR: The epigenome may control the expression of local or distal genes with critical functions in myocardial stress response and if epigenomic patterns track with disease progression, assays for the methylation scores may be useful for assessing prognosis in heart failure.
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Exercise induces new cardiomyocyte generation in the adult mammalian heart.
Ana Vujic,Carolin Lerchenmüller,Ting-Di Wu,Ting-Di Wu,Christelle Guillermier,Christelle Guillermier,Charles P Rabolli,Emilia Gonzalez,Samuel E. Senyo,Xiaojun Liu,Jean-Luc Guerquin-Kern,Jean-Luc Guerquin-Kern,Matthew L. Steinhauser,Richard T. Lee,Anthony Rosenzweig +14 more
TL;DR: It is shown that intensive exercise leads to a 4.6-fold increase in murine cardiomyocyte proliferation requiring the expression of miR-222, and that exercise induces an extendedCardiomyogenic response in the murine heart after infarction.
Structural basis for potency differences between GDF8 and GDF11.
Ryan G. Walker,Magdalena Czepnik,Erich J Goebel,Jason C. McCoy,Ana Vujic,Miook Cho,Juhyun Oh,Senem Aykul,Kelly L. Walton,Kelly L. Walton,Gauthier Schang,Daniel J. Bernard,Andrew P. Hinck,Craig A. Harrison,Craig A. Harrison,Erik Martinez-Hackert,Amy J. Wagers,Richard T. Lee,Thomas B. Thompson +18 more
TL;DR: It is shown that, despite their high similarity, GDF11 is a more potent activator of SMAD2/3 and signals more effectively through the type I activin-like receptor kinase receptors ALK4/5/7 than GDF8.
Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice.
Jason D. Roh,Nicholas E. Houstis,Andy Yu,Bliss J. Chang,Ashish Yeri,Haobo Li,Ryan Hobson,Carolin Lerchenmüller,Ana Vujic,Vinita Chaudhari,Federico Damilano,Colin Platt,Daniel A. Zlotoff,Richard T. Lee,Ravi V. Shah,Michael Jerosch-Herold,Anthony Rosenzweig +16 more
TL;DR: In this paper, the role of aging biology in heart failure with preserved ejection fraction (HFpEF) in older adults was investigated in a C57BL/6 male mouse, and it was shown that ExT in old mice improved exercise capacity, diastolic function, and contractile reserves, while reducing pulmonary congestion.
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Mitochondrial redox and TCA cycle metabolite signaling in the heart.
TL;DR: In this article, a review of the sources of ROS in the heart, mitochondrial metabolite dynamics, and current cardioprotective strategies relevant to mitochondrial ROS is presented, focusing on current cardiomyocyte protection strategies.
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