Ana Romarowski
Instituto de Biología y Medicina Experimental
21 Papers
25 Citations
Ana Romarowski is an academic researcher from Instituto de Biología y Medicina Experimental. The author has contributed to research in topics: Capacitation & Sperm. The author has an hindex of 10, co-authored 14 publications. Previous affiliations of Ana Romarowski include Shimane University & University of Massachusetts Amherst.
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Papers
Molecular Basis of Human Sperm Capacitation.
Lis C. Puga Molina,Guillermina Maria Luque,Paula A. Balestrini,Clara I. Marín-Briggiler,Ana Romarowski,Mariano G. Buffone +5 more
TL;DR: This review is focused on the principal molecular mechanisms that govern human sperm capacitation with particular emphasis on comparing all the reported pieces of evidence with the mouse model.
Mouse sperm begin to undergo acrosomal exocytosis in the upper isthmus of the oviduct.
Florenza Antonella la Spina,Lis C. Puga Molina,Ana Romarowski,Alejandra Mariel Vitale,Tomás L. Falzone,Tomás L. Falzone,Dario Krapf,Noritaki Hirohashi,Mariano G. Buffone +8 more
TL;DR: In this paper, double transgenic mouse sperm were used to determine physiological sites of exocytosis in the female reproductive tract, and it was shown that a significant proportion of sperm initiate AE in the upper segments of the oviductal isthmus.
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PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosis.
Ana Romarowski,Maria A. Battistone,Florenza Antonella la Spina,Lis C. Puga Molina,Guillermina Maria Luque,Alejandra Mariel Vitale,Patricia S. Cuasnicú,Pablo E. Visconti,Dario Krapf,Mariano G. Buffone +9 more
TL;DR: This work demonstrated for the first time that the master regulators of actin dynamics in somatic cells are present and active in mouse sperm and proposed a working model regarding how LIMK1 and Cofilin control acrosomal exocytosis in mice sperm.
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A Specific Transitory Increase in Intracellular Calcium Induced by Progesterone Promotes Acrosomal Exocytosis in Mouse Sperm
Ana Romarowski,Claudia Sánchez-Cárdenas,Héctor Vicente Ramírez-Gómez,Lis C. Puga Molina,Claudia L. Treviño,Arturo Hernández-Cruz,Alberto Darszon,Mariano G. Buffone +7 more
TL;DR: This study investigated the spatiotemporal correlation between the changes in [Ca2+]i and AR in single mouse spermatozoa in response to progesterone and found that only a specific transitory increase in Ca2+i originating in the sperm head promotes the initiation of AR.
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CFTR/ENaC-dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC.
Lis C. Puga Molina,Nicolás A. Pinto,Nicolás Torres,Ana Laura González-Cota,Guillermina Maria Luque,Paula A. Balestrini,Ana Romarowski,Dario Krapf,Celia M. Santi,Claudia L. Treviño,Alberto Darszon,Mariano G. Buffone +11 more
TL;DR: It is demonstrated for the first time, that NBC cotransporters and ENaC channels are essential in the CFTR-dependent activation of the cAMP/PKA signaling pathway and Em regulation during human sperm capacitation.
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