Ana M. Valdes
University of Nottingham
381 Papers
3.1K Citations
Ana M. Valdes is an academic researcher from University of Nottingham. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 84, co-authored 334 publications. Previous affiliations of Ana M. Valdes include University of California, San Francisco & Hoffmann-La Roche.
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Papers
Metabolomic study of carotid-femoral pulse-wave velocity in women.
Cristina Menni,Massimo Mangino,Marina Cecelja,Maria Psatha,M J Brosnan,Jeff K. Trimmer,Robert P. Mohney,Phil Chowienczyk,Sandosh Padmanabhan,Tim D. Spector,Ana M. Valdes +10 more
TL;DR: Circulating levels of uridine, phenylacetylglutamine, and serine appear strongly correlated with PWV in women, suggesting the regulation of arterial stiffening is regulated by endothelial nitric oxide synthase phosphorylation.
The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study
Kalliope Panoutsopoulou,Sarah Metrustry,Sally A Doherty,Laura L Laslett,Rose A. Maciewicz,Deborah J. Hart,Deborah J. Hart,Weiya Zhang,Kenneth Muir,Margaret Wheeler,Cyrus Cooper,Tim D. Spector,Tim D. Spector,Flavia M. Cicuttini,Graeme Jones,Nigel K Arden,Nigel K Arden,Nigel K Arden,Michael Doherty,Eleftheria Zeggini,Ana M. Valdes +20 more
TL;DR: In this article, the role of the FTO polymorphism rs8044769 in risk of knee and hip OA in cases and controls incorporating body mass index (BMI) information was examined.
Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis
Hanneke J. M. Kerkhof,Michael Doherty,Nigel K Arden,Nigel K Arden,Steven B. Abramson,Mukundan Attur,Steffan D. Bos,Cyrus Cooper,Cyrus Cooper,Elaine M. Dennison,Sally A Doherty,Evangelos Evangelou,Deborah J. Hart,A. Hofman,Kassim Javaid,Irina Kerna,Kalle Kisand,Margreet Kloppenburg,Svetlana Krasnokutsky,Rose A. Maciewicz,Ingrid Meulenbelt,Kenneth Muir,Fernando Rivadeneira,Jonathan Samuels,Melek Sezgin,Eline Slagboom,Anthony J. Smith,Tim D. Spector,Ann Tamm,André G. Uitterlinden,Margaret Wheeler,Guangju Zhai,Weiya Zhang,J.B. van Meurs,Ana M. Valdes +34 more
TL;DR: The meta-analysis of six published studies retrieved from the literature search and eight unpublished studies showed no evidence of association between common genetic variation in the IL1B or IL1RN genes and risk of hip OA or knee OA, but the data suggest that IL1 RN might have a role in severity of knee Oa.
Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.
Glenys Thomson,Ana M. Valdes,Ana M. Valdes,Janelle A. Noble,Ingrid Kockum,Mark N. Grote,Mark N. Grote,J. Najman,Henry A. Erlich,Henry A. Erlich,Francesco Cucca,Alberto Pugliese,Ann R. Steenkiste,J. S. Dorman,Sophie Caillat-Zucman,Robert Hermann,Robert Hermann,Jorma Ilonen,Jorma Ilonen,A. P. Lambert,Polly J. Bingley,Kathleen M Gillespie,Åke Lernmark,CB Sanjeevi,Kjersti S. Rønningen,Dag E. Undlien,Erik Thorsby,Antonio Petrone,Raffaella Buzzetti,B. P. C. Koeleman,Bart O. Roep,Güher Saruhan-Direskeneli,F.A. Uyar,Hülya Günöz,C. Gorodezky,C. Alaez,Bernhard O. Boehm,Wojciech Młynarski,Hiroshi Ikegami,M. Berrino,M. E. Fasano,E. Dametto,Shoshana Israel,Chaim Brautbar,A. Santiago-Cortes,T. Frazer de Llado,Jin-Xiong She,T. L. Bugawan,T. L. Bugawan,Jerome I. Rotter,Leslie J. Raffel,Adina Zeidler,F. Leyva-Cobian,B. R. Hawkins,Soh Ha Chan,Luis Castaño,Flemming Pociot,Jørn Nerup +57 more
TL;DR: The results show that meta-analyses and use of the P/C ratio and rankings thereof can be valuable in determining T1D risk factors at the haplotype and amino acid residue levels.
Race‐specific type 1 diabetes risk of HLA‐DR7 haplotypes
TL;DR: Testing the hypothesis that closely related human leukocyte antigen (HLA) haplotypes containing the DRB1*07:01 gene ['DR7') derived from European and African populations differ in their genetic susceptibility for type 1 diabetes (T1D) depending on the DQ-α molecule present found the presence of DQA1*03:01 renders the DR7 haplotype not protective but also creates a haplotype with significant T1D risk.