Ana M. Basso
AbbVie
20 Papers
269 Citations
Ana M. Basso is an academic researcher from AbbVie. The author has contributed to research in topics: Methylazoxymethanol acetate & Antipsychotic. The author has an hindex of 12, co-authored 20 publications. Previous affiliations of Ana M. Basso include Abbott Laboratories.
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Papers
eIF2B activator prevents neurological defects caused by a chronic integrated stress response.
Yao Liang Wong,Lauren LeBon,Ana M. Basso,Kathy L. Kohlhaas,Arthur L. Nikkel,Holly M. Robb,Diana Donnelly-Roberts,Janani Prakash,Andrew M. Swensen,Nimrod D. Rubinstein,Swathi Krishnan,Fiona E. McAllister,Nicole V Haste,Jonathon J. O’Brien,Margaret Ann Roy,Andrea T. Ireland,Jennifer M. Frost,Lei Shi,Stephan Riedmaier,Kathleen A. Martin,Michael J. Dart,Carmela Sidrauski +21 more
TL;DR: It is shown that introduction of a human VWM mutation into mice leads to persistent ISR induction in the central nervous system and long-term treatment with a small molecule eIF2B activator, 2BAct, prevents all measures of pathology and normalizes the transcriptome and proteome of VWM mice.
172
Patent
Method of treating depression using a TNF-alpha antibody
Rebecca S Hoffman,Michael W. Decker,Ana M. Basso,Lynne E. Rueter,Walid M. Abi-Saab +4 more
- 18 Aug 2006
TL;DR: In this article, the authors described methods of treating depression comprising administering a TNFα antibody, such as a human TNFβ antibody, to a patient, such that the patient's depression was alleviated.
108
Chronic low dose risperidone and clozapine alleviate positive but not negative symptoms in the rat neonatal ventral hippocampal lesion model of schizophrenia.
Lynne E. Rueter,Michael E. Ballard,Kelly B. Gallagher,Ana M. Basso,Peter Curzon,Kathy L. Kohlhaas +5 more
TL;DR: These data add further support to the neonatal VH lesion model as a predictive pharmacological screening assay for identifying compounds effective in the treatment of positive symptoms of schizophrenia.
82
Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test.
Ana M. Basso,Kelly B. Gallagher,Natalie A. Bratcher,Jorge D. Brioni,Robert B. Moreland,Gin C. Hsieh,Karla Drescher,Gerard B. Fox,Michael W. Decker,Lynne E. Rueter +9 more
TL;DR: The pharmacological selectivity of the compounds tested suggests that the antidepressant-like effects of quinpirole are most likely mediated mainly by D2 and to a lesser extent by D3 but not D4 receptors.
82
Preclinical evaluation of non-imidazole histamine H3 receptor antagonists in comparison to atypical antipsychotics for the treatment of cognitive deficits associated with schizophrenia.
TL;DR: Results suggest H(3)R antagonists may have the potential to ameliorate CDS and chronic, but not acute, treatment with ABT-239 significantly improved spontaneous alternation impairments in MAM rats tested in cross-maze.