Ana E. Gabriel

TL;DR: In this article, the authors identify elements of the immune response as critical mediators of intrinsic RPE regeneration and demonstrate that macrophage/microglia cells are responsive to RPE damage and that their function is required for the timely progression of the regenerative response.

TL;DR: To the knowledge, these data are the first to identify the molecular and cellular underpinnings of RPE regeneration in any system and hold significant potential for translational approaches aimed towards promoting a pro-regenerative environment in mammalian RPE.

TL;DR: A zebrafish transgenic model that enabled ablation of large swathes of mature RPE resulted in rapid RPE degeneration, as well as degeneration of Bruch’s membrane and underlying photoreceptors and it is proved that Wnt signaling is required for RPE regeneration.

TL;DR: The authors note that Supporting Table S11 in the SI Appendix appeared incorrectly: “The sequences for the rpe65a forward qRT-PCR primer and the reverse qRT PCR primer are both incorrect.”