Ana do Vale
University of Porto
43 Papers
224 Citations
Ana do Vale is an academic researcher from University of Porto. The author has contributed to research in topics: Photobacterium damselae & Biology. The author has an hindex of 17, co-authored 37 publications. Previous affiliations of Ana do Vale include Novartis & Instituto de Biologia Molecular e Celular.
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Papers
Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications
TL;DR: In vivo secondary necrosis occurs when massive apoptosis overwhelms the available scavenging capacity, or when the scavenger mechanism is directly impaired, and may result in leakage of the cell contents with induction of tissue injury and inflammatory and autoimmune responses.
Bacterial Toxins as Pathogen Weapons Against Phagocytes
Ana do Vale,Ana do Vale,Didier Cabanes,Didier Cabanes,Sandra Maria Zákia Lian Sousa,Sandra Maria Zákia Lian Sousa +5 more
TL;DR: This review will concentrate on toxins from Gram-positive and Gram-negative bacteria that manipulate cell signaling or induce cell death by either imposing direct damage to the host cells cytoplasmic membrane or enzymatically modifying key eukaryotic targets.
AIP56, a novel plasmid-encoded virulence factor of Photobacterium damselae subsp. piscicida with apoptogenic activity against sea bass macrophages and neutrophils
Ana do Vale,Manuel T. Silva,Nuno M.S. dos Santos,Diana S. Nascimento,Pedro Reis-Rodrigues,Carolina Costa-Ramos,Anthony E. Ellis,Jorge E. Azevedo +7 more
TL;DR: In this article, a plasmid-encoded apoptosis inducing protein of 56 kDa (AIP56), an exotoxin abundantly secreted by all virulent, but not avirulent, Phdp strains tested, was shown to represent a key virulence factor of that pathogen and is a candidate for the design of an antipasteurellosis vaccine.
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Caspase-1 and IL-1β Processing in a Teleost Fish
Marta Reis,Marta Reis,Ana do Vale,Pedro Pereira,Jorge E. Azevedo,Jorge E. Azevedo,Nuno M.S. dos Santos +6 more
TL;DR: It is shown that sea bass caspase-1 auto-processing is similar to that of the human enzyme, resulting in active p24/p10 and p20/ p10 heterodimers, and it is shown That sea bass and avian IL-1β are specifically cleaved by caspases at different but phylogenetically conserved aspartates, distinct from the cleavage site of mammalian IL- 1β.
Apoptosis of sea bass (Dicentrarchus labrax L.) neutrophils and macrophages induced by experimental infection with Photobacterium damselae subsp. piscicida
TL;DR: The infection of sea bass by intraperitoneal injection of the agent of fish pasteurellosis Photobacterium damselae subsp.
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