An Wang
7 Papers
7 Citations
An Wang is an academic researcher. The author has contributed to research in topics: Antibody & Neutralizing antibody. The author has an hindex of 2, co-authored 3 publications.
Chat about Author
Papers
Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys.
Shuang Wang,Yun Peng,Rongjuan Wang,Shasha Jiao,Min Wang,Weijin Huang,Chao Shan,Wen Jiang,Zepeng Li,Chunying Gu,Ben Chen,Xue Hu,Yanfeng Yao,Juan Min,Huajun Zhang,Ying Chen,Ge Gao,Peipei Tang,Gang Li,An Wang,Lan Wang,Jinchao Zhang,Shuo Chen,Xun Gui,Zhiming Yuan,Datao Liu +25 more
TL;DR: A monoclonal antibody, MW05, with SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor is reported.
Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment
Rongjuan Wang,Chang Zhang,Yuting Cao,Junchao Wang,Shasha Jiao,Xiao Zhang,Min Wang,Peipei Tang,Zijun Ouyang,Wenlu Liang,Yuhui Mao,An Wang,Gang Li,Jin-chao Zhang,Mingzhu Wang,Shuang Wang,Xun Gui +16 more
TL;DR: Wang et al. as mentioned in this paper reported the development of a bispecific antibody 6MW3211 to block both PD-1/PD-L1 and CD47/SIRPα signals.
An antibody-dependent enhancement (ADE) activity eliminated neutralizing antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
Shuang Wang,Yun Peng,Rongjuan Wang,Shasha Jiao,Min Wang,Weijin Huang,Chao Shan,Wen Jiang,Zepeng Li,Chunying Gu,Ben Chen,Xue Hu,Yanfeng Yao,Juan Min,Huajun Zhang,Ying Chen,Ge Gao,Peipei Tang,Gang Li,An Wang,Lan Wang,Shuo Chen,Xun Gui,Jinchao Zhang,Zhiming Yuan,Datao Liu +25 more
TL;DR: A monoclonal antibody, MW05, is reported showing high SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor by introducing the LALA mutation to the Fc region (MW05/LALA).
7
Association of home-and community-based services with health-related quality of life among Chinese older adults
Chen Wei,Zhou Xu,Di-Juan Meng,An Wang,Dong Hua,Quantong Zhu,Gang Li +6 more
Pre-Clinical Development of a Potent Neutralizing Antibody MW3321 With Extensive SARS-CoV-2 Variants Coverage
Wen Jiang,Zhe-Rui Zhang,Yuhe Zhu,Ben Chen,Chunying Gu,Zhiyan Liu,Xukai Zhang,Hualong Xiong,Ya-Nan Zhang,Bin Zheng,Rongjuan Wang,Shasha Jiao,An Wang,Jinchao Zhang,Shuang Wang,Bo Zhang,Gang Li,Xun Gui +17 more
TL;DR: Data support the development of MW3321 as a monotherapy or cocktail against SARS-CoV-2-related diseases and could effectively reduce viral burden in hACE2-transgenic mice challenged with either wild-type or Delta Sars-Cov-2 strains through viral neutralization and Fc-mediated effector functions.