Amy Won
University of Toronto
20 Papers
83 Citations
Amy Won is an academic researcher from University of Toronto. The author has contributed to research in topics: Peptide & Peripheral membrane protein. The author has an hindex of 13, co-authored 20 publications. Previous affiliations of Amy Won include Ryerson University & Carleton University.
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Papers
Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane
Takashi Hirama,Takashi Hirama,Raibatak Das,Yanbo Yang,Yanbo Yang,Charles Ferguson,Amy Won,Christopher M. Yip,Jason G. Kay,Sergio Grinstein,Robert G. Parton,Gregory D. Fairn,Gregory D. Fairn +12 more
TL;DR: It is concluded that the predominant plasmalemmal anionic lipid PtdSer is essential for proper Cav clustering, caveola formation, and caveola dynamics and that membrane scrambling can perturb caveolar stability.
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An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.
Joel M J Tan,Nora Mellouk,Suzanne E. Osborne,Dustin A. Ammendolia,Diana N Dyer,Ren Li,Diede Brunen,Jorik M. van Rijn,Ju Huang,Mark A. Czuczman,Marija Cemma,Amy Won,Christopher M. Yip,Ramnik J. Xavier,Donna A. MacDuff,Fulvio Reggiori,Fulvio Reggiori,Jayanta Debnath,Tamotsu Yoshimori,Peter K. Kim,Gregory D. Fairn,Gregory D. Fairn,Etienne Coyaud,Brian Raught,Brian Raught,Aleixo M. Muise,Darren E. Higgins,John H. Brumell +27 more
TL;DR: It is shown that autophagy-related protein ATG16L1 and its binding partners ATG5 and ATG12 are required for plasma membrane repair through a pathway independent of macroautophagy, and help to restrict Listeria monocytogenes toxin-mediated cell-to-cell spread.
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Characterization of a Basidiomycota hydrophobin reveals the structural basis for a high-similarity Class I subdivision.
Julie-Anne Gandier,David N. Langelaan,Amy Won,Kylie A. O’Donnell,Julie L. Grondin,Holly L. Spencer,Philip Wong,Elisabeth R. M. Tillier,Christopher M. Yip,Steven P. Smith,Emma R. Master +10 more
TL;DR: The first structure and solution properties of a unique Class I protein sequence of Basidiomycota origin: the Schizophyllum commune hydrophobin SC16 (hyd1), which has surface properties and secondary structure elements reminiscent of both Class I and II hydrophobins.
Investigating the effect of a single glycine to alanine substitution on interactions of antimicrobial peptide latarcin 2a with a lipid membrane
TL;DR: Data indicate that decrease in the flexibility of ltc2a induced by the modification in the hinge region is likely to increase the peptide’s nonspecific interactions with zwitterionic cell membranes and potentially increase its toxicity against eukaryotic cells.
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Investigating the effects of L- to D-amino acid substitution and deamidation on the activity and membrane interactions of antimicrobial peptide anoplin
Amy Won,Mourin Khan,Sorin Gustin,Akuvi Akpawu,Deeptee Seebun,Tyler J. Avis,Bonnie O. Leung,Adam P. Hitchcock,Anatoli Ianoul +8 more
TL;DR: The results suggest that amidated forms of peptides are likely to possess higher membrane binding affinity due to the increased charge and membrane lytic activity of all derivatives was found to depend strongly on membrane composition and lipid/peptide ratio.
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