Amy R. Strom
Howard Hughes Medical Institute
6 Papers
Amy R. Strom is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Heterochromatin & Histone methylation. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Amy R. Strom include University of California, Berkeley & Lawrence Berkeley National Laboratory.
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Papers
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization
David W. Sanders,Nancy Kedersha,Daniel S.W. Lee,Amy R. Strom,Victoria Drake,Joshua A. Riback,Dan Bracha,Jorine M. Eeftens,Allana Iwanicki,Alicia Wang,Ming-Tzo Wei,Gena Whitney,Shawn M. Lyons,Paul A. Anderson,William M. Jacobs,Pavel Ivanov,Clifford P. Brangwynne,Clifford P. Brangwynne +17 more
TL;DR: Inspired by patchy colloid theory, this work proposes a general framework by which competing networks give rise to compositionally specific and tunable condensates, while relative linkage between nodes underlies multiphase organization.
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Nucleated transcriptional condensates amplify gene expression.
Ming-Tzo Wei,Yi-Che Chang,Shunsuke F. Shimobayashi,Yongdae Shin,Yongdae Shin,Amy R. Strom,Clifford P. Brangwynne,Clifford P. Brangwynne +7 more
TL;DR: It is found that TAF15 has a unique charge distribution among the FET family members that enhances its interactions with the C-terminal domain of RNA polymerase II, suggesting that positive feedback between interacting transcriptional components drives localized phase separation to amplify gene expression.
Hp1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Amy R. Strom,Ronald J Biggs,Edward J. Banigan,Xiaotao Wang,Katherine Chiu,Cameron Herman,Jimena Collado,Feng Yue,Joan C. Ritland Politz,Leah J Tait,David Scalzo,Agnes Telling,Mark Groudine,Clifford P. Brangwynne,John F. Marko,Andrew D. Stephens +15 more
TL;DR: In this paper, the authors used a novel HP1α auxin-inducible degron human cell line to rapidly degrade HP 1α (CBX5) and found that HP 1 α is essential to chromatin-based mechanics and maintains nuclear morphology.
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The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.
Joel M Swenson,Serafin U Colmenares,Amy R. Strom,Amy R. Strom,Sylvain V. Costes,Gary H. Karpen,Gary H. Karpen +6 more
TL;DR: It is concluded that heterochromatin composition and architecture is more spatially complex and dynamic than previously suggested, and proposed that a network of subdomains regulates diverse heterochROMatin functions.
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Amy R. Strom,Ronald J Biggs,Edward J. Banigan,Xiaotao Wang,Katherine Chiu,Cameron Herman,Jimena Collado,Feng Yue,Joan C. Ritland Politz,Leah J Tait,David Scalzo,Agnes Telling,Mark Groudine,Clifford P. Brangwynne,John F. Marko,Andrew D. Stephens +15 more
TL;DR: Heterochromatic histone methylation controls nucleus and chromosome stiffness and HP1α is a critical chromatin-crosslinking protein that provides mechanical strength to chromosomes and the nucleus throughout the cell cycle and supports cellular functions.