Amy E. Solinski
Emory University
11 Papers
Amy E. Solinski is an academic researcher from Emory University. The author has contributed to research in topics: Chemistry & Gene. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Amy E. Solinski include Temple University.
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Papers
Targeting S. mutans biofilms: a perspective on preventing dental caries.
TL;DR: An overview of the current small molecule strategies used for targeting S. mutans biofilms, and a perspective of the future for the field are provided.
Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms
Amy E. Solinski,Alexander B. Koval,Richard S. Brzozowski,Kelly R. Morrison,Americo J. Fraboni,Carrie E. Carson,Anisa R. Eshraghi,Guangfeng Zhou,Robert G. Quivey,Vincent A. Voelz,Bettina A. Buttaro,William M. Wuest +11 more
TL;DR: The diverted total synthesis and biological evaluation of a rationally designed library of simplified analogs that unveiled three unique biofilm phenotypes further validating the role of natural product synthesis in the discovery of new biological phenomena is reported.
A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism.
Cristian Ochoa,Amy E. Solinski,Marcus Nowlan,Madeline M Dekarske,William M. Wuest,Marisa C. Kozlowski +5 more
TL;DR: In this paper, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined, and mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition.
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The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.
Weining Zhao,Ashley R. Cross,Caillan Crowe-McAuliffe,Angela Weigert‐Munoz,Erika E Csatary,Amy E. Solinski,Joanna Krysiak,Joanna B. Goldberg,Daniel N. Wilson,Eva Medina,William M. Wuest,Stephan A. Sieber +11 more
TL;DR: Elegaphenone enhanced the elimination of intracellular P. aeruginosa in macrophages exposed to sub-inhibitory concentrations of the fluoroquinolone antibiotic norfloxacin and provided unique insights into the mode of action.
Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans.
TL;DR: The discovery of a simplified carolacton-inspired analog is disclosed that demonstrates inhibitory activity against S. mutans biofilm cells and permitted a proof of concept chemical genetic screen of S.Âmutans mutants identifying the carbon catabolite protein A signaling pathway as a putative target.
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