45 Papers
112 Citations
Amit Arora is an academic researcher from Council of Scientific and Industrial Research. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 14, co-authored 30 publications. Previous affiliations of Amit Arora include Queen's University Belfast & Post Graduate Institute of Medical Education and Research.
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Papers
Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes.
TL;DR: This work evaluated the hybridization thermodynamics of a series of LNA-substituted DNA octamers, modified to various extents by one to three LNA substitutions, introduced at either adenine ( 5'-AGCACCAG) or thymine (5'-TGCTCCTG) nucleotides.
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Prediction and classification of ncRNAs using structural information
TL;DR: This work conclusively demonstrates that a simple feature, tri-nucleotide composition, is sufficient to discriminate between coding and non-coding RNA sequences and graph properties based feature set along with RandomForest algorithm are most suitable to classify different ncRNA classes.
Binding of berberine to human telomeric quadruplex - spectroscopic, calorimetric and molecular modeling studies.
Amit Arora,Chandramouli Balasubramanian,Niti Kumar,Saurabh Agrawal,Rajendra Prasad Ojha,Souvik Maiti +5 more
TL;DR: The molecular modeling studies on different quadruplex–berberine complexes show that berberine stacking at the external G‐quartet is mainly aided by the π–π interaction and the stabilization of the high negative charge density of O6 of guanines by the positively charged N7 of berberines.
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Differential biophysical behavior of human telomeric RNA and DNA quadruplex.
Amit Arora,Souvik Maiti +1 more
TL;DR: It is observed that the RNA quadruplex adopts a parallel conformation and displays remarkably high thermal stabilities as compared to its DNA counterpart, and UV titration experiments showed that both human telomeric RNA and DNA quadruplexes possess similar recognition abilities for TMPyP4 molecules.
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Effect of loop orientation on quadruplex-TMPyP4 interaction.
Amit Arora,Souvik Maiti +1 more
TL;DR: The study emphasizes that differences in the loop orientation give rise to different conformations of quadruplex, which in turn govern its binding to small molecules, and thereby play a pivotal role in molecular recognition.
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