Amirhossein Sakhteman
Shiraz University of Medical Sciences
103 Papers
252 Citations
Amirhossein Sakhteman is an academic researcher from Shiraz University of Medical Sciences. The author has contributed to research in topics: Chemistry & Docking (molecular). The author has an hindex of 16, co-authored 82 publications. Previous affiliations of Amirhossein Sakhteman include Tehran University of Medical Sciences & Shiraz University.
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Papers
Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors
Ali Asadipour,Masoumeh Alipour,Mona Jafari,Mehdi Khoobi,Saeed Emami,Hamid Nadri,Amirhossein Sakhteman,Alireza Moradi,Vahid Sheibani,Farshad Homayouni Moghadam,Abbas Shafiee,Alireza Foroumadi,Alireza Foroumadi +12 more
TL;DR: The kinetic study revealed that compound 10c exhibited mixed-type inhibition against AChE, and protein-ligand docking study demonstrated that the target compounds have dual binding site interaction mode, in agreement with kinetic study.
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Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.
Seyyede Faeze Razavi,Mehdi Khoobi,Hamid Nadri,Amirhossein Sakhteman,Alireza Moradi,Saeed Emami,Alireza Foroumadi,Abbas Shafiee +7 more
TL;DR: The docking study of the most potent compound 4m, indicated that Phe330 is responsible for ligand recognition and trafficking by forming π-cation interaction with benzylpiperidine moiety, which could stabilize the ligand in the active site resulting in more potent inhibition of the enzyme.
112
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors
Masoumeh Alipour,Mehdi Khoobi,Alireza Foroumadi,Hamid Nadri,Alireza Moradi,Amirhossein Sakhteman,Mehdi Ghandi,Abbas Shafiee +7 more
TL;DR: A novel series of coumarin derivatives linked to benzyl pyridinium group were synthesized and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinease (BuChE).
110
Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors
Mehdi Khoobi,Masoumeh Alipour,Amirhossein Sakhteman,Hamid Nadri,Alireza Moradi,Mehdi Ghandi,Saeed Emami,Alireza Foroumadi,Alireza Foroumadi,Abbas Shafiee +9 more
TL;DR: The 1-(4-fluorobenzyl)pyridinium derivative 6g showed the most potent anti-AChE activity and the highest AChE/BuChE selectivity (SI>48).
99
Synthesis and antimycobacterial activity of some alkyl [5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates.
Alireza Foroumadi,Zahra Kargar,Amirhossein Sakhteman,Zahra Sharifzadeh,Robabeh Feyzmohammadi,Mahnoush Kazemi,Abbas Shafiee +6 more
TL;DR: Two series of 2- and 3-[5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio, sulfinyl and sulfonyl] propionic acid alkyl esters were synthesized and screened for antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system.
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