Three new nano sized Cu(II), Co(II) and Ni(II) complexes of imine ligand derived from the condensation of 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared and investigated using various chemical techniques such as NMR, elemental analysis, molar conductance, IR, electronic spectra, TGA and magnetic moment measurements. The obtained chemical analysis data showed that the synthesis of 1:1 (metal:ligand) ratio and octahedral geometry was proposed on the basis of magnetic moment and spectral data studies except the Cu(II) complex which is tetrahedral geometry. Nano-sized particles of the investigated complexes were prepared by sonochemistry method. Furthermore, metal oxides nanoparticles were gained by calcination of the prepared corresponding complexes at 500°C and their structures were characterized by powder x-ray and transmittance electron microscopy. Moreover, the free ligand, its complexes and their metal oxides have been checked in vitro against a number of bacteria and fungi in order to assess their antimicrobial activities. In addition to that, DNA binding of the prepared complexes was tested by many routes such as electronic spectra, viscosity and gel electrophoresis. The results showed that the investigated complexes could bind to DNA via an intercalative mode. The cytotoxicity of the Schiff base complexes on human colon carcinoma cells, (HCT-116 cell line) and Breast carcinoma cells, (MCF-7 cell line) showed potent cytotoxicity effect against growth of carcinoma cells compared to the clinically used Vinblastine standard.

Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu(II), Co(II) and Ni(II) chelates based on tri-dentate NOO imine ligands as precursors for metal oxides.

Bioinorganic antimicrobial strategies in the resistance era

Synthesis and spectroscopic properties of new azo-dyes and azo-metal complexes derived from barbituric acid and aminoquinoline

The influence of metals in biology has become more and more apparent within the past century. Metal ions perform essential roles as critical scaffolds for structure and as catalysts in reactions. Speciation is a key concept that assists researchers in investigating processes that involve metal ions. However, translation of the essential area across scientific fields has been plagued by language discrepancies. To rectify this, the IUPAC Commission provided a framework in which speciation is defined as the distribution of species. Despite these attempts, contributions from inorganic chemists to the area of speciation have not fully materialized in part because the past decade's contributions focused on technological advances, which are not yet to the stage of measuring speciation distribution in biological solutions. In the following, we describe how speciation influences the area of metals in medicine and how speciation distribution has been characterized so far. We provide two case studies as an illustration, namely, vanadium and iron. Vanadium both has therapeutic importance and is known as a cofactor for metalloenzymes. In addition to being a cation, vanadium(V) has analogy with phosphorus and as such is a potent inhibitor for phosphorylases. Because speciation can change the metal's existence in cationic or anionic forms, speciation has profound effects on biological systems. We also highlight how speciation impacts iron metabolism, focusing on the rather low abundance of biologically relevant iron cation that actually exists in biological fluids. fluids. Furthermore, we point to recent investigations into the mechanism of Fenton chemistry, and that the emerging results show pH dependence. The studies suggest formation of Fe(IV)-intermediates and that the generally accepted mechanism may only apply at low pH. With broader recognition toward biological speciation, we are confident that future investigations on metal-based systems will progress faster and with significant results. Studying metal complexes to explore the properties of a potential "active species" and further uncovering the details associated with their specific composition and geometry are likely to be important to the action.

Metal speciation in health and medicine represented by iron and vanadium

Single and simultaneous adsorption of pefloxacin and Cu(II) ions from aqueous solutions by oxidized multiwalled carbon nanotube.

Schiff bases of the type salicylidene 2-aminobenzothiazole and o-nitrobenzylidene 2-aminobenzothiazole were prepared by condensation of 2-aminobenzothiazole with salicylaldehyde and o-nitrobenzaldehyde. The bases react with cobalt(II), nickel(II) and copper(II) chlorides to give 1:1 and 1:2 complexes. Electronic spectra, magnetic susceptibility measurements and infrared data are used to infer the structures. The thermal decomposition of the complexes and evaluation of the thermodynamic parameters are also reported.

Studies on Some Schiff Base Complexes of CoII, NiII and CuII Derived from Salicylaldehyde and O-Nitrobenzaldehyde

Complexing properties of nucleic-acid constituents adenine and guanine complexes.

New azo compounds containing barbituric acid, thiobarbituric acid or thiouracil, together with their complexes, were prepared. All the complexes are tetrahedral. Axial ESR spectra were observed for the complexes with a dx2� y2 ground state with small g|| values indicating strong interaction between the ligands and their metal ions. Conductivity measurements proved semiconducting properties for the ligands and their complexes. Energies of activation (Ea) and order of the thermal reactions (n) were calculated by DTA.

/pdf/synthesis-and-characterization-of-new-azopyrimidine-178x5yq76h.pdf

Synthesis and characterization of new azopyrimidine complexes

Coordination modes, spectral, thermal and biological evaluation of hetero-metal copper containing 2-thiouracil complexes.

https://cyberleninka.org/article/n/488910.pdf

Syntheses, structural elucidation, thermal properties, theoretical quantum chemical studies (DFT) and biological studies of barbituric–hydrazone complexes

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