Ami Yanagi
9 Papers
8 Citations
Ami Yanagi is an academic researcher. The author has contributed to research in topics: Chemistry & Bile Salt Export Pump. The author has an hindex of 6, co-authored 9 publications.
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Papers
Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice.
Yuji Ishida,Chihiro Yamasaki,Ami Yanagi,Yasumi Yoshizane,Kazuyuki Fujikawa,Koichi Watashi,Hiromi Abe,Takaji Wakita,C. Nelson Hayes,Kazuaki Chayama,Chise Tateno +10 more
TL;DR: Chimeric mouse-derived HHs provide a robust in vitro infection model that can completely support the HBV life cycle and are reported a highly effective in vitro HBV infection system using fresh human hepatocytes isolated from chimeric mice with humanized livers.
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Generation and characterization of severe combined immunodeficiency rats.
Tomoji Mashimo,Akiko Takizawa,Junya Kobayashi,Yayoi Kunihiro,Kazuto Yoshimi,Saeko Ishida,Koji Tanabe,Ami Yanagi,Asato Tachibana,Jun Hirose,Jun-ichiro Yomoda,Shiho Morimoto,Takashi Kuramoto,Birger Voigt,Takeshi Watanabe,Hiroshi Hiai,Chise Tateno,Kenshi Komatsu,Tadao Serikawa +18 more
TL;DR: Xenotransplantation of human induced pluripotent stem cells, ovarian cancer cells, and hepatocytes shows that SCID and FSG rats can act as hosts for xenogeneic tissue grafts and stem cell transplantation and may be useful for preclinical testing of new drugs.
78
Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs
Chihiro Yamasaki,Yuji Ishida,Ami Yanagi,Yasumi Yoshizane,Yuha Kojima,Yuko Ogawa,Yutaka Kageyama,Yumiko Iwasaki,Seiichi Ishida,Kazuaki Chayama,Chise Tateno +10 more
TL;DR: The characteristics of fresh h-hepatocytes isolated from chimeric mice with humanized livers evaluated in vitro suggest that cFHHs could be a novel in vitro tool for drug development studies.
Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions.
Naoki Takaoka,Seigo Sanoh,Katsuhiro Okuda,Yaichiro Kotake,Go Sugahara,Ami Yanagi,Yuji Ishida,Chise Tateno,Yoshitaka Tayama,Kazumi Sugihara,Shigeyuki Kitamura,Mami Kurosaki,Mineko Terao,Enrico Garattini,Shigeru Ohta +14 more
TL;DR: In vitro data indicate species‐specific and substrate‐dependent differences in the inhibitory effects on AOX activity and demonstrate the existence of a DDI which may be of relevance in the clinical context.
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Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers.
Yuji Ishida,Chihiro Yamasaki,Hiroko Iwanari,Hisahiko Yamashita,Yuko Ogawa,Ami Yanagi,Suzue Furukawa,Yuha Kojima,Kazuaki Chayama,Kazuaki Chayama,Junichi Kamiie,Chise Tateno +11 more
TL;DR: The results implicate the humanized liver mice and derived fresh human hepatocytes are useful models for studies of AFB1 cytotoxicity to human hepatocyte studies.