Amber Smith
5 Papers
1 Citations
Amber Smith is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 5 publications.
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Papers
Patient-derived micro-organospheres enable clinical precision oncology.
Sheng Ding,C. Hsu,Zhao-xia Wang,Naveen Natesh,R. E. Millen,Marcos Negrete,N Giroux,Grecia O. Rivera,Anders B. Dohlman,Shree Bose,Tomer Rotstein,Kassandra V. Spiller,Athena Yeung,Zhiguo Sun,Chongming Jiang,Rui Xi,Benjamin D. Wilkin,Peggy M. Randon,Ian O. Williamson,Daniel Nelson,Daniel Delubac,Sehwa Oh,Gabrielle Rupprecht,James Isaacs,Jing Jia,Chao-Hu Chen,John Paul Shen,Scott Kopetz,Shannon J. McCall,Amber Smith,Nikolce Gjorevski,Antje Walz,Scott J. Antonia,Estelle Marrer-Berger,Hans Clevers,David S. Hsu,Xiling Shen +36 more
TL;DR: In this paper , the authors used droplet emulsion microfluidics with temperature control and dead-volume minimization to rapidly generate thousands of micro-organospheres (MOSs) from low-volume patient tissues, which serve as an ideal patient-derived model for clinical precision oncology.
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Rapid tissue prototyping with micro-organospheres
Zhao-xia Wang,Matteo Boretto,R. E. Millen,Naveen Natesh,Elena S. Reckzeh,C. Hsu,Marcos Negrete,Haipei Yao,William Quayle,Brook E. Heaton,Alfred T. Harding,Shree Bose,Else Driehuis,Joep Beumer,Grecia O. Rivera,Ravian L. van Ineveld,Donald Gex,Jessica DeVilla,Daisong Wang,Jens Puschhof,Maarten H. Geurts,Athena Yeung,Cait E. Hamele,Amber Smith,Eric D. Bankaitis,Kun Xiang,Sheng Ding,Daniel Nelson,Daniel Delubac,Anne C. Rios,Ralph Abi-Hachem,David W. Jang,Bradley J. Goldstein,Carolyn M. Glass,Nicholas S. Heaton,David S. Hsu,Hans Clevers,Xiling Shen +37 more
TL;DR: Micro-organospheres (MOSs) as mentioned in this paper are droplet-encapsulated miniature three-dimensional (3D) tissue models that can be established rapidly from patient tissues or cells.
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Microorganospheres as a novel precision oncology platform in colorectal cancer.
C. Hsu,Zhao-xia Wang,Sehwa Oh,Gabrielle Rupprecht,Kelly J. Pittman,Amber Smith,Daniel Delubac,Xiling Shen,Jing Jia,S. David Hsu +9 more
TL;DR: The ability to generate MOS and perform a drug screen in < 14 days will allow for the development of a precision oncology platform that can be rapidly used in the clinic to guide therapy.
2
Establishing functional models of peritoneal carcinomatosis using MicroOrganoSphere (MOS) technology.
A. Yousef,Aaron L. McCormick,Amber Smith,Ichiaki Ito,Mahmoud Gamal Yousef,M. Zeineddine,Beth A. Helmink,M. White,Keith Fournier,Daniel Delubac,Xiling Shen,John Paul Shen +11 more
TL;DR: In this paper , the authors created functional tumoroid models (MicroOrganoSpheres or MOS) of peritoneal carcinomatosis from appendix cancer and mesothelioma and used these MOS to test the efficacy of different chemotherapy treatments.
Complete Remission of Widely Metastatic Human Epidermal Growth Factor Receptor 2–Amplified Pancreatic Adenocarcinoma After Precision Immune and Targeted Therapy With Description of Sequencing and Organoid Correlates
D. King,Amber Smith,Gino Pineda,Michitaka Nakano,Flavia Michelini,S. Peter Goedegebuure,Sheeno Thyparambil,Wei Liao,Aaron K. McCormick,Jihang Ju,Michele Cioffi,Xiuli Zhang,Jasreet Hundal,Malachi Griffith,Carla Grandori,Rachele Rosati,Astrid Margossian,Payel Chatterjee,T. Ainge,Marta Flory,Paolo S. Ocampo,Lee-may Chen,George A. Poultsides,Ari David Baron,Daniel T. Chang,Joseph M. Herman,William E. Gillanders,Haeseong Park,William Arthur Hoos,Mike Nichols,George A. Fisher,Calvin J. Kuo +31 more
TL;DR: Daniel A. King, MD, PhD; Amber R. Smith, PhD, Gino Pineda, Michitaka Nakano, MD- PhD; Flavia Michelini, PhD and Calvin J. Kuo as discussed by the authors .