Amanda Mitchell
Princess Margaret Cancer Centre
39 Papers
516 Citations
Amanda Mitchell is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Stem cell & Leukemia. The author has an hindex of 11, co-authored 28 publications. Previous affiliations of Amanda Mitchell include University Health Network & University of Toronto.
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Papers
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
A 17-gene stemness score for rapid determination of risk in acute leukaemia
Stanley W.K. Ng,Amanda Mitchell,James A. Kennedy,James A. Kennedy,James A. Kennedy,Weihsu C. Chen,Jessica McLeod,Narmin Ibrahimova,Andrea Arruda,Andreea C. Popescu,Vikas Gupta,Vikas Gupta,Vikas Gupta,Aaron D. Schimmer,Andre C. Schuh,Andre C. Schuh,Andre C. Schuh,Karen W.L. Yee,Karen W.L. Yee,Karen W.L. Yee,Lars Bullinger,Tobias Herold,Tobias Herold,Dennis Görlich,Thomas Büchner,Wolfgang Hiddemann,Wolfgang Hiddemann,Wolfgang E. Berdel,Bernhard Wörmann,Meyling Cheok,Claude Preudhomme,Hervé Dombret,Klaus H. Metzeler,Klaus H. Metzeler,Christian Buske,Bob Löwenberg,Peter J. M. Valk,Peter W. Zandstra,Mark D. Minden,John E. Dick,John E. Dick,Jean C.Y. Wang,Jean C.Y. Wang,Jean C.Y. Wang +43 more
TL;DR: The LSC17 score provides clinicians with a rapid and powerful tool to identify AML patients who do not benefit from standard therapy and who should be enrolled in trials evaluating novel upfront or post-remission strategies.
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Tracing the origins of relapse in acute myeloid leukaemia to stem cells
Liran I. Shlush,Liran I. Shlush,Amanda Mitchell,Lawrence E. Heisler,Sagi Abelson,Stanley W.K. Ng,Aaron Trotman-Grant,Jessie J. F. Medeiros,Abilasha Rao-Bhatia,Ivana Jaciw-Zurakowsky,Rene Marke,Jessica McLeod,Monica Doedens,Gary D. Bader,Veronique Voisin,Changjiang Xu,John Douglas Mcpherson,Thomas J. Hudson,Thomas J. Hudson,Jean C.Y. Wang,Jean C.Y. Wang,Jean C.Y. Wang,Mark D. Minden,John E. Dick,John E. Dick +24 more
TL;DR: Combined genetic and functional analysis of purified subpopulations and xenografts from paired diagnosis/relapse samples are identified, identifying therapy-resistant cells already present at diagnosis and two major patterns of relapse.
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Corrigendum: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, called a “shots fired” process.
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells
Eric R. Lechman,Eric R. Lechman,Bernhard Gentner,Stanley W.K. Ng,Erwin M. Schoof,Erwin M. Schoof,Peter van Galen,Peter van Galen,James A. Kennedy,James A. Kennedy,Silvia Nucera,Fabio Ciceri,Kerstin B. Kaufmann,Kerstin B. Kaufmann,Naoya Takayama,Naoya Takayama,Stephanie M. Dobson,Stephanie M. Dobson,Aaron Trotman-Grant,Aaron Trotman-Grant,Gabriela Krivdova,Gabriela Krivdova,Janneke Elzinga,Janneke Elzinga,Amanda Mitchell,Amanda Mitchell,Björn Nilsson,Karin G. Hermans,Karin G. Hermans,Kolja Eppert,Rene Marke,Ruth Isserlin,Veronique Voisin,Gary D. Bader,Peter W. Zandstra,Todd R. Golub,Benjamin L. Ebert,Jun Lu,Mark D. Minden,Mark D. Minden,Jean C.Y. Wang,Jean C.Y. Wang,Luigi Naldini,John E. Dick,John E. Dick +44 more
TL;DR: Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.
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