Amanda E. Sinha
University of Washington
7 Papers
387 Citations
Amanda E. Sinha is an academic researcher from University of Washington. The author has contributed to research in topics: Two-dimensional chromatography & Chemometrics. The author has an hindex of 7, co-authored 7 publications.
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Papers
Trilinear chemometric analysis of two-dimensional comprehensive gas chromatography-time-of-flight mass spectrometry data.
TL;DR: This manuscript demonstrates how the selectivity of GC x GC/TOFMS combined with trilinear chemometric techniques such as tril inear decomposition (TLD) and parallel factor analysis (PARAFAC) results in a powerful analytical methodology.
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Algorithm for locating analytes of interest based on mass spectral similarity in GC × GC–TOF-MS data: analysis of metabolites in human infant urine
TL;DR: This algorithm was investigated with a trimethylsilyl (TMS) derivatized human infant urine sample that contained organic acid metabolites and found it to address the need to rapidly identify analyte peak locations in gas chromatography x gas Chromatography-time of flight mass spectrometry data.
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Multivariate selectivity as a metric for evaluating comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry subjected to chemometric peak deconvolution.
Amanda E. Sinha,Janiece L. Hope,Bryan J. Prazen,Carlos G. Fraga,Erik Nilsson,Robert E. Synovec +5 more
TL;DR: A region of GC x GC-TOFMS data from a complex natural sample of a derivatized metabolic plant extract from Huilmo was analyzed using TLD/PARAFAC, demonstrating the utility of this analytical technique on a natural sample containing overlapped analytes without selective ions or peak shape assumptions.
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Comprehensive two-dimensional gas chromatography of volatile and semi-volatile components using a diaphragm valve-based instrument.
Amanda E. Sinha,Kevin J. Johnson,Bryan J. Prazen,Samuel V. Lucas,Carlos G. Fraga,Robert E. Synovec +5 more
TL;DR: A new configuration is described that extends the working temperature range of diaphragm valve-based GCxGC instruments to significantly higher temperatures, so both volatile and semi-volatile compounds can be readily separated.
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Valve-based comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometric detection: instrumentation and figures-of-merit.
TL;DR: The valve-based GC x GC instrument is shown to have high chromatographic resolution, high separation efficiency and low detection limits, and offers a simple, rugged and less expensive alternative to thermally modulated instruments.
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