Amanda Denuc
University of Barcelona
8 Papers
116 Citations
Amanda Denuc is an academic researcher from University of Barcelona. The author has contributed to research in topics: Ubiquitin & Biology. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Amanda Denuc include Carlos III Health Institute.
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Papers
SUMO and ubiquitin paths converge.
Amanda Denuc,Gemma Marfany +1 more
TL;DR: Several cases in which SUMOylation and ubiquitination intersect are reviewed, showing also that the same protein can be conjugated to SUMO and Ub for antagonistic, synergistic or multiple outcomes, illustrating the intricacy of the cellular signalling networks.
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The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition.
TL;DR: It is shown that mutation of K99 clearly diminished USP25-dependent rescue of the specific substrate MyBPC1 from proteasome degradation, thereby supporting a new mechanistic model, in which USP 25m is regulated through alternative conjugation of ubiquitin or SUMO to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains.
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Stepwise assembly of the Nova-regulated alternative splicing network in the vertebrate brain
Manuel Irimia,Amanda Denuc,Demian Burguera,Ildiko M. L. Somorjai,José M. Martín-Durán,Grigory Genikhovich,Senda Jiménez-Delgado,Ulrich Technau,Scott William Roy,Gemma Marfany,Jordi Garcia-Fernàndez +10 more
TL;DR: The step-by-step assembly of the vertebrate splicing network regulated by Nova, a splicing factor that modulates alternative splicing in the vertebrates central nervous system by binding to clusters of YCAY motifs on pre-RNA transcripts, is reconstructed.
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Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1.
Manuel Irimia,Amanda Denuc,José Luis Ferran,Barbara Pernaute,Luis Puelles,Scott William Roy,Jordi Garcia-Fernàndez,Gemma Marfany +7 more
TL;DR: A-to-I RNA editing has been shown to improve protein half-life and protein stability in the brain this article, which is a key brain-specific regulator of alternative splicing.
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© 2012 Landes Bioscience. Do not distribute. Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1
Manuel Irimia,Amanda Denuc,José Luis Ferran,Barbara Pernaute,Luis Puelles,Scott William Roy,Jordi Garcia-Fernàndez,Gemma Marfany,Facultat de Biología +8 more
- 01 Jan 2012
TL;DR: A-to-I RNA editing is shown in Nova1, a key brain-specific regulator of alternative splicing, revealing the novel role of RNA editing in regulating protein stability, and establishing protein stability as a new target of multifaceted regulation.
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