Aman Wang
Dalian Medical University
23 Papers
47 Citations
Aman Wang is an academic researcher from Dalian Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 11 publications.
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Papers
USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma
Zhen Ning,Xin Guo,Xiaolong Liu,Chang Lu,Aman Wang,Xiaolin Wang,Wen Wang,Huan Chen,Wangshu Qin,Xinyu Liu,Lina Zhou,Chi Ma,Jian Du,Zhikun Lin,Haifeng Luo,Wuxiyar Otkur,Huan Qi,Di Chen,Tian Xia,Jiwei Liu,Guang Tan,Guowang Xu,Hai-long Piao +22 more
TL;DR: In this article , the ubiquitin-specific protease 22 (USP22) was identified as a key regulator for de novo fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome proliferator-activated receptor gamma (PPARγ) through K48-linked deUBiquitination, and in turn this stabilization increases acetyl-CoA carboxylase (ACC) and ATP citrate lyase (ACLY) expressions.
USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma.
Chang Lu,Zhen Ning,Aman Wang,Di Chen,Xiaolong Liu,Tian Xia,Dinesh Singh Tekcham,Wen Wang,Li Tongming,Liu Xiumei,Jing Liu,Huan Qi,Haifeng Luo,Jian Du,Chi Ma,Qiu Yan,Jiwei Liu,Guowang Xu,Hai-long Piao,Guang Tan +19 more
TL;DR: The results uncover an undescribed mechanism where USP10, as a tumor suppressor, negatively regulates mTORC1 activation and AKT phosphorylation by stabilizing AMPKα and PTEN in HCC cells.
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USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
TL;DR: The dual mechanism of USP22 involvement in cisplatin resistance is revealed that USP 22 can regulate γH2AX-mediated DNA damage repair and Ku70/Bax-mediated apoptosis and should be considered in future therapeutic practice.
Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer
Jin-Xiao Liang,Zhen Ning,Wei Gao,Jun Ling,Aman Wang,Hai-Feng Luo,Yong Liang,Qiu Yan,Zhongyu Wang +8 more
TL;DR: A new function of USP22 is demonstrated that induces autophagy, thus leading to the poor prognosis of pancreatic cancer, and is found to enhance cell proliferation and resistance to starvation and chemotherapeutic drugs in Panc‑1 cells.
[Corrigendum] USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β‑catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma
TL;DR: The authors apologize to the Editor and to the readership of the Journal for any inconvenience caused and agree to this correction.
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