Alons Lends
17 Papers
7 Citations
Alons Lends is an academic researcher. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 3, co-authored 3 publications.
Chat about Author
Papers
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.
Kaspars Tars,Daniela Vullo,Andris Kazaks,Janis Leitans,Alons Lends,Aiga Grandane,Raivis Zalubovskis,Andrea Scozzafava,Claudiu T. Supuran +8 more
TL;DR: It is demonstrated that sulfocoumarins (1, 2-benzoxathiine 2,2-dioxides) possess a similar mechanism of action, acting as effective CA inhibitors, and the X-ray structure of one of these compounds in adduct with a modified CA II enzyme possessing two amino acid residues allowed us to decipher the inhibition mechanism.
210
Halogen-bonded shape memory polymers
Hongshuang Guo,Rakesh Puttreddy,Turkka Salminen,Alons Lends,Kristaps Jaudzems,Hao Zeng,Arri Priimagi +6 more
TL;DR: In this paper , a liquid crystalline network comprising permanent covalent crosslinks and dynamic halogen bond crosslinks, which possess reversible thermo-responsive shape memory behavior, is reported, enabling temporary shape fixation at room temperature and subsequent shape recovery in response to human body temperature.
Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients
Kristi̅ne Kru̅kle-Be̅rziṇa,Alons Lends,Anna Boguszewska-Czubara +2 more
TL;DR: Cyclodextrin metal-organic frameworks (CD MOFs) are explored as a cost-efficient and low-toxicity drug delivery system for APIs, with γCD-K MOFs showing promise for encapsulating carmofur, 5-fluorouracil, and salicylic acid, reducing their toxicity levels.
8
Efficient 18.8 T MAS-DNP NMR reveals hidden side chains in amyloid fibrils
Alons Lends,Nicolas Birlirakis,Xinyi Cai,Asen Yotov Daskalov,Jayakrishna Shenoy,Muhammed Bilal Abdul-Shukkoor,Mélanie Berbon,Fabien Ferrage,Yanping Liu,Antoine Loquet,Kong Ooi Tan +10 more
TL;DR: In this paper , high-field dynamic nuclear polarization (DNP), an NMR hyperpolarization technique typically performed at low temperatures, can circumvent this issue because the low-temperature environment (~ 100 K) slows down the protein dynamics to escape unfavorable detection regime, and DNP improves the overall NMR sensitivity including those of flexible side chains.
Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy
Zigmantas Toleikis,Raitis Bobrovs,Agne Janoniene,Alons Lends,Mantas Ziaunys,Ieva Baronaite,V. Petrauskas,Kristīne Kitoka,Vytautas Smirnovas,Kristaps Jaudzems +9 more
TL;DR: It is shown that α-syn interacts with S100A9 at specific regions, which are also essential in the first step of aggregation, and it is demonstrated that the 4-fluorophenylalanine label in alpha-synuclein is a sensitive probe to study interaction and aggregation using 19F NMR spectroscopy.