Alon Chen
8 Papers
Alon Chen is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2
Juan Pablo Lopez,M. Lücken,Elena Brivio,Stoyo Karamihalev,Aron Kos,Carlo De Donno,Asaf Benjamin,Huanqing Yang,Alec L.W. Dick,Rainer Stoffel,Cornelia Flachskamm,Andrea Ressle,S. Roeh,Rosa-Eva Huettl,Andrea Parl,Carola Eggert,Bozidar Novak,Yu-Han Yan,Kar Chuan Yeoh,Maria Holzapfel,B. Hauger,D. Harbich,Bianca Schmid,Rossella Di Giaimo,Christoph W. Turck,Mathias V. Schmidt,Jan M. Deussing,Matthias Eder,Julien Dine,Fabian J. Theis,Alon Chen +30 more
TL;DR: In this paper , the Kcnq2 gene was identified as an important downstream regulator of ketamine action in glutamatergic neurons of the ventral hippocampus, and the authors showed that adjunctive treatment with retigabine, a KCNQ activator, augments ketamine's antidepressant-like effects in mice.
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Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus.
Elena Brivio,Aron Kos,Alessandro Francesco Ulivi,Stoyo Karamihalev,Andrea Ressle,Rainer Stoffel,Dana Hirsch,Gil Stelzer,Mathias V. Schmidt,Juan Pablo Lopez,Alon Chen +10 more
TL;DR: The contribution of cell types to transcriptional sex dimorphism using single-cell RNA sequencing finds cell-type-specific signatures of acute restraint stress in the paraventricular nucleus of the hypothalamus, a central hub of the stress response in male and female mice.
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Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus
Aron Kos,Juan Pablo Lopez,Joeri Bordes,C. De Donno,Julien Dine,Elena Brivio,Stoyo Karamihalev,Malte D Luecken,Suellen Almeida-Correa,Serena Gasperoni,Alec Dick,Lucas Miranda,Maren Büttner,Rainer Stoffel,Cornelia Flachskamm,Fabian J. Theis,Mathias V. Schmidt,Alon Chen +17 more
TL;DR: This study significantly advances the understanding of the molecular, physiological, and behavioral alterations induced by ELA, uncovering a previously unknown cell type–specific vulnerability to ELA.
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The co-chaperone FKBP51 modulates HPA axis activity and age-related maladaptation of the stress system in pituitary proopiomelanocortin cells
L. Brix,Alexander S. Häusl,Irmak Toksöz,Joeri Bordes,Lotte van Doeselaar,Clara Engelhardt,Sowmya V. Narayan,Margherita Springer,V. Sterlemann,Jan M. Deussing,Alon Chen,Mathias V. Schmidt +11 more
TL;DR: In this article , a combination of endogenous knockout and viral rescue was used to show that male mice lacking FKBP51 in Pomc-expressing cells exhibit enhanced glucocorticoid (GC)-mediated negative feedback and are protected from age-related disruption of their diurnal corticosterone (CORT) rhythm.
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Chapter 18 - Stress and its effects across generations
Olivia Engmann,Isabelle M. Mansuy,Alon Chen +2 more
- 01 Jan 2020
TL;DR: Factors that may contribute to the controversy of this novel research field are discussed, including the importance of critical periods, stressor type, and other nongenetic modes of transmission.
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