Allison Bischoff
4 Papers
Allison Bischoff is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications.
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Papers
Arginase 1 is a key driver of immune suppression in pancreatic cancer
Rosa E. Menjivar,Zeribe C. Nwosu,Wenting Du,Katelyn Donahue,Carlos Espinoza,Kristee Brown,Ashley Velez-Delgado,Wei Yan,Fatima Lima,Allison Bischoff,Padma Kadiyala,Daniel J. Salas-Escabillas,Howard C. Crawford,Filip Bednar,Eileen Carpenter,Yang Zhang,Christopher J. Halbrook,Costas A. Lyssiotis,Marina Pasca di Magliano +18 more
TL;DR: Genetic inactivation of Arg1 in macrophages and treatment with the arginase inhibitor CB-1158 exhibited further increased CD8+ T cell infiltration, beyond that seen with the macrophage-specific knockout, and sensitized the tumors to anti-PD1 immune checkpoint blockade.
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Abstract C049: WT1+ cancer-associated fibroblasts promote pancreatic cancer growth
TL;DR: Bischoff et al. as mentioned in this paper used single-cell RNA-sequencing (scRNA-seq) to identify pancreatic stellate cells, mesothelial and tissue-resident fibroblasts as progenitors to subsets of cancer-associated CAFs.
Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions
Eileen S. Carpenter,Ahmed M. Elhossiny,Padma Kadiyala,Jay Li,Jake McGue,Brian D Griffith,Yang Zhang,Jacob Edwards,Sarah Nelson,Fatima Lima,Katelyn Donahue,Wenting Du,Allison Bischoff,Danyah Alomari,Hannah R Watkoske,Michael Mattea,S. The,Carlos Espinoza,Meredith Barrett,Christopher J. Sonnenday,Nicholas Olden,Chin-Tung Chen,Nicole Peterson,Valerie Gunchick,Vaibhav Sahai,Arvind Rao,Filip Bednar,Jiaqi Shi,Timothy L. Frankel,Marina Pasca di Magliano +29 more
TL;DR: A comprehensive characterization of the healthy adult human pancreas reveals frequent neoplastic lesions with a unique microenvironment and early activation of pathways as discussed by the authors , which indicates that the pathway activation may be early.
Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions
Eileen S. Carpenter,Ahmed M. Elhossiny,Padma Kadiyala,Jay Li,Jake McGue,Brian D Griffith,Yang Zhang,Jacob Edwards,Sarah Nelson,Fatima Lima,Katelyn Donahue,Wenting Du,Allison Bischoff,Danyah Alomari,Hannah R Watkoske,Michael Mattea,S. The,Carlos Espinoza,Meredith Barrett,Christopher J. Sonnenday,Nicholas Olden,Nicole Peterson,Valerie Gunchick,Vaibhav Sahai,Arvind Rao,Filip Bednar,Jiaqi Shi,Timothy L. Frankel,Marina Pasca di Magliano +28 more
TL;DR: In this article , the authors used a combination of multiplex immunohistochemistry, single cell RNA sequencing, and spatial transcriptomics to characterize the unique microenvironment of the adult human pancreas and sporadic PanIN lesions.