Alix Sémat
5 Papers
146 Citations
Alix Sémat is an academic researcher. The author has contributed to research in topics: Keratin & Cellular differentiation. The author has an hindex of 5, co-authored 5 publications.
Chat about Author
Papers
•Journal Article
Reexpression of fetal characters in simian virus 40-transformed human keratinocytes.
TL;DR: It is shown that transformation by SV40 results in the coordinate reexpression of a whole set of fetal characters, including a set of three keratin polypeptides, which is present in much larger amounts in SVK14 cells than in HE-SV cells.
Mesenchymal-epithelial conversions induced by 5-azacytidine: appearance of cytokeratin Endo-A messenger RNA.
TL;DR: Cloned DNA probes are used to demonstrate that, in 1246 fibroblasts, 5 AzaC induces the appearance of Endo-A mRNA, which was found to be the same as that in epithelial cells which normally express this RNA.
40
Sequence analysis of murine cytokeratin endo A (n° 8) cDNA. Evidence for mRNA species initiated upstream of the normal 5′end in PCC4 cells
TL;DR: Analysis of the protein sequence deduced showed that the Endo A protein presented all the characteristics of intermediate filaments, including an alpha-helical central rod domain and nonhelical N- and C-termini, and a high degree of homology to keratin 8 of other species was observed.
29
Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression.
TL;DR: The nucleotide sequence of a 1700 bp-long cDNA encoding human epidermal keratin No. 10 exhibits the characteristic features of an acidic keratin with a constant central rod domain and C-terminal variable structures.
17
A keratin of fetal skin is reexpressed in human keratinocytes transformed by SV40 virus or treated with the tumor promoter TPA
TL;DR: SV40-transformation as well as treatment with tumor promoters produce alterations in morphology, differentiation and keratinization of human keratinocytes, which suggests that SV40 virus and TPA are able to induce in human Keratinocytes the reexpression of fetal characters.
13