Alison M. Bates
Indiana University
6 Papers
10 Citations
Alison M. Bates is an academic researcher from Indiana University. The author has contributed to research in topics: Telomere & Telomerase. The author has an hindex of 3, co-authored 5 publications.
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Papers
Hachimoji DNA and RNA. A Genetic System with Eight Building Blocks
Shuichi Hoshika,Nicole A. Leal,Myong Jung Kim,Myong Sang Kim,Nilesh B. Karalkar,Hyo Joong Kim,Alison M. Bates,Norman E. Watkins,Holly A. SantaLucia,Adam J. Meyer,Saurja DasGupta,Joseph A. Piccirilli,Andrew D. Ellington,John SantaLucia,Millie M. Georgiadis,Steven A. Benner +15 more
TL;DR: DNA- and RNA-like systems built from eight nucleotide “letters” that form four orthogonal pairs that meet the structural requirements needed to support Darwinian evolution, including a polyelectrolyte backbone, predictable thermodynamic stability, and stereoregular building blocks that fit a Schrödinger aperiodic crystal are reported.
The Role and Therapeutic Potential of miRNAs in Colorectal Liver Metastasis.
Smiti Snigdha Sahu,Shatovisha Dey,Sarah C. Nabinger,Guanglong Jiang,Guanglong Jiang,Alison M. Bates,Hiromi Tanaka,Yunlong Liu,Janaiah Kota +8 more
TL;DR: In this paper, the authors analyzed miRNA expression in 405 patient tumors from publicly available colorectal cancer genome sequencing project database and found that ectopic expressions of miR-378f, -605 and -1976 suppress CRC cell proliferation, anchorage independent growth, metastatic potential, and enhance apoptosis.
Onset of Telomere Dysfunction and Fusions in Human Ovarian Carcinoma
TL;DR: In this paper, the authors explored the telomere dynamics in patient-derived epithelial ovarian cancers (OC), a malignancy characterized by multiple distinct subtypes, extensive molecular heterogeneity, and widespread genomic instability.
Onset of Telomere Dysfunction and Fusions in Human Ovarian Carcinoma
Nazmul Huda,Yan Xu,Alison M. Bates,Deborah A. Rankin,Nagarajan Kannan,David Gilley +5 more
- 04 May 2019
TL;DR: A high frequency of telomere fusions in ovarian tumor tissues is discovered and relatively high levels of both telomerase activity and hTERT expression, along with anaphase bridges in tumor tissues are found, which were notably absent in adjacent normal ovarian tissues and benign lesions.
Widespread telomere instability in prostatic lesions.
LiRen Tu,Nazmul Huda,Brenda R. Grimes,Roger B. Slee,Alison M. Bates,Liang Cheng,David Gilley +6 more
TL;DR: Evidence is presented of high levels of telomere dysfunction in BPH, an established early precursor and prostate cancer lesions but not generally in tumor adjacent normal tissue, suggesting that telomeres dysfunction may be a common gateway event leading to genomic instability in prostate tumorigenesis.