Alison H. Goodall
University of Leicester
200 Papers
5.1K Citations
Alison H. Goodall is an academic researcher from University of Leicester. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 65, co-authored 197 publications. Previous affiliations of Alison H. Goodall include Leicester Royal Infirmary & AMIT.
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Papers
Differential effects of native and oxidatively modified low-density lipoproteins on platelet function.
TL;DR: The data indicate that the extent of oxidation of LDL is critical in determining their effects on platelet function, possibly due to the presence of lipid hydroperoxides near to the concentration range found in pathological states.
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A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential
Ares Rocanin-Arjo,William Cohen,Laure Carcaillon,Laure Carcaillon,Corinne Frere,Noémie Saut,Luc Letenneur,Martine Alhenc-Gelas,Anne-Marie Dupuy,Marion Bertrand,Marie-Christine Alessi,Marine Germain,Philipp S. Wild,Tanja Zeller,François Cambien,Alison H. Goodall,Philippe Amouyel,Pierre-Yves Scarabin,Pierre-Yves Scarabin,David-Alexandre Trégouët,Pierre-Emmanuel Morange +20 more
TL;DR: In vitro functional experiments demonstrated that supplementing normal plasma with increasing orosomucoid concentrations was associated with impaired thrombin generation, paving the way for novel mechanistic pathways and therapeutic perspectives in the etiology of thrombotic disorders.
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Gemfibrozil reduces thrombin generation in patients with combined hyperlipidaemia, without influencing plasma fibrinogen, fibrin gel structure or coagulation factor VII.
Anders Bröijersén,Anders Hamsten,Angela Silveira,Kamaran Fatah,Alison H. Goodall,M. Eriksson,Bo Angelin,Paul Hjemdahl +7 more
TL;DR: Gemfibrozil reduced thrombin generation in men with combined hyperlipoproteinaemia, without influencing the plasma levels of fibrinogen, VIIa and XIIa, or fibr in gel structure.
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ADP causes partial degranulation of platelets in the absence of aggregation
TL;DR: ADP is capable of causing partial degranulation of platelets independently of aggregation, fibrinogen binding or thrombin generation, and release of potent procoagulant, vasoactive and mitogenic substances from the platelets could continue in the presence ofThrombin inhibitors and GPIIb‐IIIa antagonists.
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Patent
Monoclonal antibodies against hepatitis b virus.
Alison H. Goodall,George Janossy,Howard C. Thomas +2 more
- 03 Apr 1981
TL;DR: The new hybridoma cell lines RF-HBs-1, RFHB-2, RF-BHs-3 and RF-CBs-4 each secrete a non-oclonal antibody to hepatitis B surface antigen.
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