Alison Baker
University of Edinburgh
10 Papers
86 Citations
Alison Baker is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Luciferase & Gene delivery. The author has an hindex of 8, co-authored 10 publications.
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Papers
Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.
Gerry McLachlan,Heather E Davidson,Emma Holder,Lee A. Davies,Ian A. Pringle,Stephanie G. Sumner-Jones,Alison Baker,Peter Tennant,Catherine Gordon,Christina Vrettou,R. Blundell,Laura Hyndman,Barbara J Stevenson,Abigail R. Wilson,Ann Doherty,Darren J. Shaw,Rebecca Coles,Hazel Painter,S H Cheng,Ronald K. Scheule,Jane C. Davies,J A Innes,S C Hyde,Uta Griesenbach,Eric W.F.W. Alton,A. C. Boyd,David J. Porteous,Deborah R. Gill,David Collie +28 more
TL;DR: The conclusion was that GL67A was the best non-viral GTA currently available for aerosol delivery to the sheep lung, led to the selection ofGL67A as the authors' lead GTA for clinical trials in CF patients.
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Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes
Lee A. Davies,Gerry McLachlan,Stephanie G. Sumner-Jones,David J. P. Ferguson,Alison Baker,Peter Tennant,Catherine Gordon,Christina Vrettou,Eilidh Baker,Jie Zhu,Eric W.F.W. Alton,David Collie,David J. Porteous,Stephen C. Hyde,Deborah R. Gill +14 more
TL;DR: It is demonstrated that concentrated pDNA/PEI formulations offer increased aerosol gene transfer with decreased inflammatory sequelae, and represents a promising advance in the field of nonviral lung gene transfer.
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Optimizing aerosol gene delivery and expression in the ovine lung.
Gerry McLachlan,Alison Baker,Peter Tennant,Catherine M. Gordon,Christina Vrettou,Louise Renwick,R. Blundell,Seng H. Cheng,Ron Scheule,Lee A. Davies,Hazel Painter,Rebecca Coles,Anna E. Lawton,Christopher Marriott,Deborah R. Gill,Stephen C. Hyde,Uta Griesenbach,Eric W.F.W. Alton,A. Christopher Boyd,David J. Porteous,David Collie +20 more
TL;DR: The sheep model can differentiate between doses of GTA and that the anticholinergic, glycopyrrolate, enhanced transgene expression is distinguished between doses, and dose-related toxicity of GTA was reduced by aerosol administration compared to direct instillation.
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Role of Alveolar Macrophages in Respiratory Transmission of Visna/Maedi Virus
Tom N. McNeilly,Alison Baker,Jeremy K. Brown,David Collie,Gerry MacLachlan,Susan Rhind,Gordon D. Harkiss +6 more
TL;DR: It is demonstrated that resident AMs are capable of VMV uptake in vivo and that this infection is associated with a specific up-regulation of AM granulocyte-macrophage colony-stimulating factor mRNA expression, which suggests that virus is transferred from AMs into the body via an intermediate route.
Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer
Uta Griesenbach,Catarina C. Vicente,Megan J. Roberts,C Meng,Samia Soussi,Stefania Xenariou,Peter Tennant,Alison Baker,Eilidh Baker,Catherine Gordon,Christina Vrettou,Dominique McCormick,Rebecca Coles,Anne-Marie Green,Anna E. Lawton,Stephanie G. Sumner-Jones,Seng H. Cheng,Ronald K. Scheule,Stephen C. Hyde,Deborah R. Gill,David Collie,Gerry McLachlan,Eric W.F.W. Alton +22 more
TL;DR: It is shown here that GLuc is a sensitive reporter gene and is particularly useful for monitoring gene transfer in difficult to transfect models of the airway and lung.
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