Alina Elizabeth Perrone
National Scientific and Technical Research Council
12 Papers
1 Citations
Alina Elizabeth Perrone is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Trypanosoma cruzi & Chagas disease. The author has an hindex of 6, co-authored 12 publications.
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Papers
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
María-Jesús Pinazo,M. Carmen Thomas,Jacqueline Búa,Alina Elizabeth Perrone,Alejandro G. Schijman,Rodolfo-Jorge Viotti,Janine-M Ramsey,Isabela Ribeiro,Sergio Sosa-Estani,Manuel-Carlos López,Joaquim Gascon +10 more
TL;DR: A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria, providing a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers.
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Trypanosoma cruzi Infection at the Maternal-Fetal Interface: Implications of Parasite Load in the Congenital Transmission and Challenges in the Diagnosis of Infected Newborns.
Patricia Bustos,Natalia Milduberger,Bibiana Julieta Volta,Alina Elizabeth Perrone,Susana A. Laucella,Jacqueline Bua +5 more
TL;DR: Improvements in detection of this parasite, with tools that can be easily adapted to be used in remote rural areas, will make the early diagnosis of infected children possible, allowing a prompt trypanocidal treatment and avoiding the current loss of opportunities for the diagnosis of 100% of T. cruzi congenitally infected infants.
A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress-damage response.
Patricia Laura Bustos,Bibiana Julieta Volta,Alina Elizabeth Perrone,Natalia Milduberger,Jacqueline Bua +4 more
TL;DR: It is described for the first time in a protozoan parasite that a mitochondrial cyclophilin is a component of the permeability transition pore and is involved in regulated cell death induced by oxidative stress.
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Phenotypic diversity and drug susceptibility of Trypanosoma cruzi TcV clinical isolates.
Luz P. Quebrada Palacio,Mariela N. González,Yolanda Hernandez-Vasquez,Alina Elizabeth Perrone,Adriana Parodi-Talice,Jacqueline Búa,Miriam Postan +6 more
TL;DR: High level of intra-type diversity in T. cruzi isolates recovered from patients with different clinical forms of Chagas disease living in Argentina may represent an important obstacle for the testing of chemotherapeutic agents.
Improved Immuno-Detection of a Low-Abundance Cyclophilin Allows the Confirmation of its Expression in a Protozoan Parasite
Patricia Bustos,Alina Elizabeth Perrone,Natalia Milduberger,Jacqueline Búa +3 more
- 06 Oct 2015
TL;DR: The combined strategy of using more specific antibodies and increasing the presence of subcellular proteins in the sample, allowed us to confirm the expression of a 21.1 kDa cyclophilin for the first time in Trypanosoma cruzi.