Alice Kwon
National Institutes of Health
4 Papers
5 Citations
Alice Kwon is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Protomer & Integrin. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
Qingbo Liu,Priyamvada Acharya,Michael A. Dolan,Peng Zhang,Christina Guzzo,Jacky Lu,Alice Kwon,Deepali Gururani,Huiyi Miao,Tatsiana Bylund,Gwo-Yu Chuang,Aliaksandr Druz,Tongqing Zhou,William J. Rice,Christoph Wigge,Bridget Carragher,Clinton S. Potter,Peter D. Kwong,Paolo Lusso +18 more
TL;DR: Cryogenic electron microscopy is used to visualize the initial contact of CD4 with the HIV-1 Env trimer at 6.8-Å resolution and documents the critical role of quaternary interactions in the initial HIV-Env-receptor contact, with implications for treatment and vaccine design.
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing
Christina Guzzo,David M. Ichikawa,Chung Park,Damilola D. Phillips,Qingbo Liu,Peng Zhang,Alice Kwon,Huiyi Miao,Jacky Lu,Catherine Rehm,James Arthos,Claudia Cicala,Myron S. Cohen,Anthony S. Fauci,John H. Kehrl,Paolo Lusso +15 more
TL;DR: In vivo treatment with an antibody to the gut-homing integrin α4β7 was shown to reduce viral transmission, delay disease progression, and induce persistent virus control in macaques challenged with simian immunodeficiency virus (SIV).
57
Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.
Peng Zhang,Jason Gorman,Hui Geng,Qingbo Liu,Yin Lin,Yaroslav Tsybovsky,Eden P. Go,Barna Dey,Tsion Andine,Alice Kwon,Mit Patel,Deepali Gururani,Ferzan Uddin,Christina Guzzo,Raffaello Cimbro,Huiyi Miao,Krisha McKee,Gwo-Yu Chuang,Loïc Martin,Francesca Sironi,Mauro S. Malnati,Heather Desaire,Edward A. Berger,John R. Mascola,Michael A. Dolan,Peter D. Kwong,Paolo Lusso +26 more
TL;DR: Interdomain stabilization provides a widely applicable template for the design of Env-based HIV-1 vaccines and elicited neutralizing antibodies against tier-2 viruses with a repaired glycan shield regardless of treatment with a functional CD4 mimic.
45
Corrigendum: Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
Qingbo Liu,Priyamvada Acharya,Michael A. Dolan,Peng Zhang,Christina Guzzo,Jacky Lu,Alice Kwon,Deepali Gururani,Huiyi Miao,Tatsiana Bylund,Gwo-Yu Chuang,Aliaksandr Druz,Tongqing Zhou,William J. Rice,Christoph Wigge,Bridget Carragher,Clinton S. Potter,Peter D. Kwong,Paolo Lusso +18 more
TL;DR: There was an incorrect comma in the introduction (after “glycoprotein” in the sentence “Upon binding to the primary cellular receptor, CD4, the external gp120 Env glycoprotein undergoes major conformational changes”).