Alice Faversani
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
19 Papers
29 Citations
Alice Faversani is an academic researcher from Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 14, co-authored 19 publications. Previous affiliations of Alice Faversani include University of Milan.
Chat about Author
Papers
Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors
Valentina Vaira,Giuseppe Fedele,Saumyadipta Pyne,Ester Fasoli,Giorgia Zadra,Dyane Bailey,Eric L. Snyder,Alice Faversani,Guido Coggi,Richard Flavin,Silvano Bosari,Massimo Loda +11 more
TL;DR: An ex vivo, reproducible, rapid and personalized culture method to investigate antitumoral pharmacological properties that preserves the original cancer microenvironment is perfected and may have a significant impact on patient selection for clinical trials and in predicting response to small-molecule inhibitor therapy.
281
PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
M. Cecilia Caino,Jagadish C. Ghosh,Young Chan Chae,Valentina Vaira,Dayana B. Rivadeneira,Alice Faversani,Paolo Rampini,Andrew V. Kossenkov,Katherine M. Aird,Rugang Zhang,Marie R. Webster,Ashani T. Weeraratna,Silvano Bosari,Lucia R. Languino,Lucia R. Languino,Dario C. Altieri +15 more
TL;DR: It is shown that small-molecule inhibitors of PI3K induce global transcriptional reprogramming in tumors, with activation of growth factor receptors, (re)phosphorylation of Akt and mammalian target of rapamycin (mTOR), and increased tumor cell motility and invasion.
189
Mismatch Repair Protein Loss as a Prognostic and Predictive Biomarker in Breast Cancers Regardless of Microsatellite Instability.
Nicola Fusco,Gianluca Lopez,Chiara Corti,Chiara Pesenti,Chiara Pesenti,Patrizia Colapietro,Patrizia Colapietro,Giulia Ercoli,Gabriella Gaudioso,Alice Faversani,Donatella Gambini,Anna Michelotti,Luca Despini,Concetta Blundo,Valentina Vaira,Valentina Vaira,Monica Miozzo,Monica Miozzo,Stefano Ferrero,Silvano Bosari +19 more
TL;DR: IMR protein loss is a more common event than MSI and shows intra-tumor heterogeneity, and MMR IHC allows the identification of clinically relevant subclasses of breast cancer patients, provided that multiple areas of the tumor are analyzed.
REGULATION OF LUNG CANCER METASTASIS BY Klf4-Numb-like SIGNALING
Valentina Vaira,Alice Faversani,Nina M. Martin,David S. Garlick,Stefano Ferrero,Mario Nosotti,Joseph L. Kissil,Silvano Bosari,Dario C. Altieri +8 more
TL;DR: The results reveal that Numbl-Klf4 signaling is critical to maintain multiple nodes of metastatic progression, including persistence of cancer-initiating cells, rationalizing its therapeutic exploitation to improve the treatment of advanced lung cancer.
63
Aberrant overexpression of the cell polarity module scribble in human cancer.
Valentina Vaira,Alice Faversani,Takehiko Dohi,Marco Maggioni,Mario Nosotti,Delfina Tosi,Dario C. Altieri,Silvano Bosari +7 more
TL;DR: It is shown that Scrib is nearly universally overexpressed in cultured tumor cell lines and genetically disparate cancer patient series compared with matched normal tissues in vivo, revealing a previously unrecognized exploitation of Scrib for aberrant tumor cell motility and invasion.
61