Aliaksei Vasilevich
Maastricht University
20 Papers
45 Citations
Aliaksei Vasilevich is an academic researcher from Maastricht University. The author has contributed to research in topics: Cell morphology & Bone regeneration. The author has an hindex of 12, co-authored 16 publications. Previous affiliations of Aliaksei Vasilevich include University of Twente & Eindhoven University of Technology.
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Papers
Data-analysis strategies for image-based cell profiling
Juan C. Caicedo,Sam Cooper,Florian Heigwer,Scott Warchal,Peng Qiu,Csaba Molnar,Aliaksei Vasilevich,Joseph Barry,Harmanjit Singh Bansal,Oren Kraus,Mathias Wawer,Lassi Paavolainen,Markus D. Herrmann,Mohammad Hossein Rohban,Jane Hung,Jane Hung,Holger Hennig,John Concannon,Ian Smith,Paul A. Clemons,Shantanu Singh,Paul Rees,Paul Rees,Peter Horvath,Peter Horvath,Roger G. Linington,Anne E. Carpenter +26 more
TL;DR: The steps required to create high-quality image-based (i.e., morphological) profiles from a collection of microscopy images are introduced and techniques that have proven useful in each stage of the data analysis process are recommended on the basis of the experience of 20 laboratories worldwide that are refining their image- based cell-profiling methodologies.
In-depth clinico-pathological examination of RNA foci in a large cohort of C9ORF72 expansion carriers.
Mariely DeJesus-Hernandez,Ni Cole A. Finch,Xue Wang,Tania F. Gendron,Kevin F. Bieniek,Michael G. Heckman,Aliaksei Vasilevich,Melissa E. Murray,Linda Rousseau,Rachael Weesner,Anthony Lucido,Meeia Parsons,Jeannie Chew,Keith A. Josephs,Joseph E. Parisi,David S. Knopman,Ronald C. Petersen,Bradley F. Boeve,Neill R. Graff-Radford,Jan de Boer,Yan W. Asmann,Leonard Petrucelli,Kevin B. Boylan,Dennis W. Dickson,Marka van Blitterswijk,Rosa Rademakers +25 more
TL;DR: This large-scale study is the first to provide conclusive evidence thatRNA foci are not the determining factor of the clinico-pathological variability observed in C9ORF72 expansion carriers and it emphasizes that the distribution of RNA foci does not follow the pattern of neurodegeneration, stressing the complex interplay between different aspects of C9 ORF72-related diseases.
Dynamic adaptation of mesenchymal stem cell physiology upon exposure to surface micropatterns.
Nick R.M. Beijer,Zarina M. Nauryzgaliyeva,Estela M. Arteaga,Laurent Pieuchot,Karine Anselme,Jeroen van de Peppel,Aliaksei Vasilevich,Nathalie Groen,Nadia J. T. Roumans,Dennie G. A. J. Hebels,Jan de Boer,Jan de Boer +11 more
TL;DR: Micro-topographies can be used as a model system to mimic the natural cell micro-environment, and be a powerful tool to optimize cell treatment in vitro, and reduce their sensitivity to certain cancer drugs.
In silico clinical trials for pediatric orphan diseases.
Aurélie Carlier,Aurélie Carlier,Aurélie Carlier,Aliaksei Vasilevich,Marina Marechal,J. de Boer,Liesbet Geris,Liesbet Geris +7 more
TL;DR: The degree of severity of CPT is significantly reduced with BMP treatment, although the effect is highly subject-specific and the potential of in silico medicine technologies as well as their implications for other orphan diseases are shown.
Micro-scaled topographies direct differentiation of human epidermal stem cells
Sebastiaan Zijl,Aliaksei Vasilevich,Priyalakshmi Viswanathan,Ayelen Luna Helling,Nick R.M. Beijer,Gernot Walko,Ciro Chiappini,Jan de Boer,Fiona M. Watt +8 more
TL;DR: In this article, the authors investigated the effect of substrate topography on epidermal stem cells and found that low topography coverage promoted differentiation of spread cells, whereas high coverage promoted the differentiation of round cells, suggesting a potential role for actin polymerization and actomyosin contraction.
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