Ali Sabahi

TL;DR: The aim of this article is to provide a review of the outstanding literature on HCV entry, specifically looking at cellular co-receptors involved and putting the data in the context of the systems used (purified viral envelope proteins, HCVpp system,HCVcc system and/or patient sera) and to also give a brief description of the cellular co theceptors themselves.

TL;DR: The high stability of the duplexes formed with propyl-, methoxyethyl- and fluoro-modified oligonucleotides correlated with high preorganization in these single-strands, despite higher thermodynamic duplex stability, hybridization kinetics to complementary DNA or RNA was slower for propyl- and methoxy methyl- modified oligon nucleotides than for the non-modified control.

TL;DR: The newly determined structure suggests that the HCV E2 ectodomain shares structural and functional similarities only with domain III of class II VFPs, which is a different mechanism than that used by class II fusion proteins for cell fusion.

TL;DR: It is shown that during infection, particles of high density disappeared from the viral inoculum sooner and initiated productive infection faster than virions of low density, demonstrating that the relationship between the density of HCVcc and thedensity of the extracellular milieu can significantly impact the rate at which HCVCC productively interacts with target cells in vitro.