Ali Danesh
Cornell University
6 Papers
Ali Danesh is an academic researcher from Cornell University. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 3, co-authored 6 publications.
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Papers
A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies.
Chase D. McCann,Christiaan H. van Dorp,Ali Danesh,Adam R. Ward,Thomas R Dilling,Talia M. Mota,Elizabeth Zale,Eva M. Stevenson,Shabnum Patel,Chanson J. Brumme,Winnie Dong,Douglas S. Jones,Thomas Lars Andresen,Bruce D. Walker,Bruce D. Walker,Zabrina L. Brumme,Zabrina L. Brumme,Catherine M. Bollard,Alan S. Perelson,Darrell J. Irvine,R. Brad Jones +20 more
TL;DR: In this paper, the authors show that the kinetics of the CD8+ T cell response have a profound impact on the emergence and persistence of escape mutations, by applying mathematical modeling.
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Roles of fragment crystallizable-mediated effector functions in broadly neutralizing antibody activity against HIV
TL;DR: The combination of antibody engineering strategies designed to enhance effector functions, with the broad and potent antigen recognition profile of bNAbs, has the potential to give rise to powerful new therapeutics for HIV.
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HIV-specific T-cell responses reflect substantive in vivo interactions with infected cells despite long-term therapy
Eva M. Stevenson,Adam R. Ward,Adam R. Ward,Ronald Truong,Allison S. Thomas,Szu-Han Huang,Szu-Han Huang,Thomas R. Dilling,Sandra Terry,John K. Bui,Talia M. Mota,Ali Danesh,Guinevere Q. Lee,Andrea Gramatica,Pragya Khadka,Winiffer D. Conce Alberto,Rajesh T. Gandhi,Deborah McMahon,Christina M. Lalama,Ronald J. Bosch,Bernard J.C. Macatangay,Joshua C. Cyktor,Joseph J. Eron,John W. Mellors,R. Brad Jones,R. Brad Jones +25 more
TL;DR: It is shown that T-cell responses to autologous reservoir viruses persist over years, and that the maintenance of HIV-Nef-specific responses was uniquely associated with residual frequencies of infected cells.
Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8+ T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency Reversal.
Talia M. Mota,Chase D. McCann,Ali Danesh,Szu-Han Huang,Dean Magat,Yanqin Ren,Louise Leyre,Tracy D. Bui,Thomas Rohwetter,Colin Kovacs,Erika Benko,Lynsay MacLaren,Avery Wimpelberg,Christopher Cannon,W. David Hardy,Jeffrey T. Safrit,R. Brad Jones,R. Brad Jones +17 more
TL;DR: It is suggested that spliced or cell-free HIV-1 RNAs are more indicative of antigen expression than unspliced HIV-RNAs and may help to explain the limited abilities of HDACi to generate CD8+ T cell targets in vivo.
A Participant-Derived Xenograft Model of HIV Enables Long-Term Evaluation of Autologous Immunotherapies
Chase D. McCann,Christiaan H. van Dorp,Adam R. Ward,Ali Danesh,Thomas R. Dilling,Talia M. Mota,Elizabeth Zale,Shabnum Patel,Chanson J. Brumme,Winnie Dong,Douglas S. Jones,Thomas Lars Andresen,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Zabrina L. Brumme,Catherine M. Bollard,Alan S. Perelson,Darrell J. Irvine,R. Brad Jones,R. Brad Jones +20 more
TL;DR: This ‘participant-derived xenograft’ model of HIV provides a powerful tool for studying HIV-specific immunological responses and facilitating the development of effective cell-based therapies.