Alfredo Castello
University of Glasgow
75 Papers
199 Citations
Alfredo Castello is an academic researcher from University of Glasgow. The author has contributed to research in topics: RNA & RNA-binding protein. The author has an hindex of 33, co-authored 70 publications. Previous affiliations of Alfredo Castello include University of Oxford & Spanish National Research Council.
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Papers
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
Alfredo Castello,Bernd Fischer,Katrin Eichelbaum,Rastislav Horos,Benedikt M. Beckmann,Claudia Strein,Norman E. Davey,David T. Humphreys,Thomas Preiss,Thomas Preiss,Lars M. Steinmetz,Jeroen Krijgsveld,Matthias W. Hentze,Matthias W. Hentze +13 more
TL;DR: Unexpectedly, it is found that many proteins of the HeLa mRNA interactome are highly intrinsically disordered and enriched in short repetitive amino acid motifs.
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A brave new world of RNA-binding proteins
TL;DR: The RNA targets and molecular and cellular functions of the new RBPs, as well as the possibility that some RBPs may be regulated by RNA rather than regulate RNA, are discussed.
Comprehensive Identification of RNA-Binding Domains in Human Cells
Alfredo Castello,Alfredo Castello,Bernd Fischer,Bernd Fischer,Christian K. Frese,Rastislav Horos,Anne-Marie Alleaume,Sophia Foehr,Tomaz Curk,Tomaz Curk,Jeroen Krijgsveld,Jeroen Krijgsveld,Matthias W. Hentze +12 more
TL;DR: This work identified 1,174 binding sites within 529 HeLa cell RBPs, discovering numerous RNA-binding domains (RBDs), which display a high degree of evolutionary conservation and incidence of Mendelian mutations, suggestive of important functional roles.
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The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs
Benedikt M. Beckmann,Rastislav Horos,Bernd Fischer,Bernd Fischer,Alfredo Castello,Alfredo Castello,Katrin Eichelbaum,Anne-Marie Alleaume,Thomas Schwarzl,Tomaž Curk,Tomaž Curk,Sophia Foehr,Wolfgang Huber,Jeroen Krijgsveld,Matthias W. Hentze +14 more
TL;DR: The in vivo RBP repertoire of the yeast Saccharomyces cerevisiae is determined and the mitochondrial hydroxysteroid dehydrogenase (HSD17B10) uncover the RNA-binding specificity of an enigmRBP, defining the coreRBP repertoire conserved from yeast to man.
hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.
Greta Pintacuda,Guifeng Wei,Chloë Roustan,Burcu Anil Kirmizitas,Nicolae Solcan,Andrea Cerase,Alfredo Castello,Shabaz Mohammed,Benoit Moindrot,Tatyana B. Nesterova,Neil Brockdorff +10 more
TL;DR: The RNA-binding protein hnRNPK is identified as the principal XR-PID binding factor required to recruit PCGF3/5-PRC1, providing important insights into mechanisms of chromatin modification by non-coding RNA.
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