Alexis Laurent
University of Paris
209 Papers
688 Citations
Alexis Laurent is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Hepatocellular carcinoma. The author has an hindex of 56, co-authored 179 publications. Previous affiliations of Alexis Laurent include Centre hospitalier universitaire Henri-Mondor & French Institute of Health and Medical Research.
Chat about Author
Papers
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
Kornelius Schulze,Sandrine Imbeaud,Eric Letouzé,Ludmil B. Alexandrov,Ludmil B. Alexandrov,Julien Calderaro,Sandra Rebouissou,Gabrielle Couchy,Clément Meiller,Jayendra Shinde,Frédéric Soysouvanh,Anna Line Calatayud,Roser Pinyol,Laura Pelletier,Charles Balabaud,Alexis Laurent,Jean-Frédéric Blanc,Vincenzo Mazzaferro,Fabien Calvo,Augusto Villanueva,Jean-Charles Nault,Paulette Bioulac-Sage,Michael R. Stratton,Josep M. Llovet,Josep M. Llovet,Jessica Zucman-Rossi +25 more
TL;DR: Exome sequencing analysis of 243 liver tumors identified mutational signatures associated with specific risk factors, mainly combined alcohol and tobacco consumption and exposure to aflatoxin B1, and defined the extensive landscape of altered genes and pathways in HCC.
1.6K
The international position on laparoscopic liver surgery: The Louisville Statement, 2008.
Joseph F. Buell,Daniel Cherqui,David A. Geller,Nicholas O'Rourke,David A. Iannitti,Ibrahim Dagher,Alan J. Koffron,M.J. Thomas,Brice Gayet,Ho-Seong Han,Go Wakabayashi,Giulio Belli,Hironori Kaneko,Chen Guo Ker,Olivier Scatton,Alexis Laurent,Eddie K. Abdalla,Prosanto Chaudhury,Erik Dutson,Clark Gamblin,Michael I. D’Angelica,David M. Nagorney,Giuliano Testa,Daniel M. Labow,Derrik Manas,Ronnie T.P. Poon,Heidi Nelson,Robert C.G. Martin,Bryan M. Clary,Wright C. Pinson,John B. Martinie,Jean Nicolas Vauthey,Robert M. Goldstein,Sasan Roayaie,David Barlet,Joseph Espat,Michael Abecassis,Myrddin Rees,Yuman Fong,Kelly M. McMasters,Christoph E. Broelsch,Ronald W. Busuttil,Jacques Belghiti,Steven M. Strasberg,Ravi S. Chari +44 more
TL;DR: Laparoscopic liver surgery is a safe and effective approach to the management of surgical liver disease in the hands of trained surgeons with experience in hepatobiliary and laparoscopic surgery, and national and international societies should become involved in the goal of establishing training standards and credentialing.
1.5K
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
Cécile Guichard,Giuliana Amaddeo,Giuliana Amaddeo,Sandrine Imbeaud,Sandrine Imbeaud,Yannick Ladeiro,Yannick Ladeiro,Laura Pelletier,Laura Pelletier,Ichrafe Ben Maad,Ichrafe Ben Maad,Julien Calderaro,Julien Calderaro,Paulette Bioulac-Sage,Mélanie Letexier,Françoise Degos,Bruno Clément,Charles Balabaud,Eric Chevet,Alexis Laurent,Gabrielle Couchy,Gabrielle Couchy,Eric Letouzé,Fabien Calvo,Jessica Zucman-Rossi,Jessica Zucman-Rossi +25 more
TL;DR: Functional analyses showed tumor suppressor properties for IRF2, whose inactivation, exclusively found in hepatitis B virus-related tumors, led to impaired TP53 function, and association of mutations in specific genes suggested that Wnt/β-catenin signaling might cooperate in liver carcinogenesis with both oxidative stress metabolism and Ras/mitogen-activated protein kinase (MAPK) pathways.
1.4K
Two-stage hepatectomy: A planned strategy to treat irresectable liver tumors.
TL;DR: Two-stage hepatectomy combined with chemotherapy may allow a long-term remission in selected patients with irresectable multiple metastases and increases the proportion of patients with resectable disease.
Liver Cirrhosis: Intravoxel Incoherent Motion MR Imaging—Pilot Study
Alain Luciani,Alexandre Vignaud,Madeleine Cavet,Jeanne Tran Van Nhieu,Ariane Mallat,Lucile Ruel,Alexis Laurent,Jean-François Deux,Pierre Brugières,Alain Rahmouni +9 more
TL;DR: Restricted diffusion observed in patients with cirrhosis may be related to D* variations, which reflect decreased perfusion, as well as alterations in pure molecular water diffusion in cirrhotic livers.
645