Alexis Haring
4 Papers
Alexis Haring is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 2 publications.
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Papers
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma
Jehan Alladina,Neal Smith,Tristan Kooistra,Kamil Slowikowski,Isabela Kernin,Jacques Deguine,Harry Keen,Kasidet Manakongtreecheep,Jessica Tantivit,Rod A. Rahimi,Alexis Haring,F. Giacona,Lida P. Hariri,Ramnik J. Xavier,Andrew D. Luster,Alexandra-Chloé Villani,Josalyn L. Cho,Benjamin D. Medoff +17 more
TL;DR: In this article , the authors compared the lower airway mucosa in allergic asthmatics and allergic non-asthmatic controls using single-cell RNA sequencing and found that the airway epithelium was highly dynamic and upregulated genes involved in matrix degradation, mucus metaplasia, and glycolysis while failing to induce injury-repair and antioxidant pathways observed in controls.
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Myofibroblast-Specific Inhibition of the Rho Kinase-MRTF-SRF Pathway Using Nanotechnology for the Prevention of Pulmonary Fibrosis.
Rachel S. Knipe,Md Nurunnabi,Clemens K. Probst,Jillian J Spinney,Elizabeth Abe,Rajendran J.C. Bose,Khanh Ha,Amanda Logue,Trong Nguyen,Rachel L. Servis,Matt Drummond,Alexis Haring,Patricia L. Brazee,Benjamin D. Medoff,J. R. McCarthy +14 more
TL;DR: In this article, the authors demonstrate a novel therapeutic anti-fibrotic strategy utilizing myofibroblast-targeted nanoparticles containing a MTRF/SRF pathway inhibitor.
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Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis.
Patricia L. Brazee,Andreane Cartier,Andrew Kuo,Alexis Haring,Trong Nguyen,Lida P. Hariri,Jason W Griffith,Timothy Hla,Benjamin D. Medoff,Rachel S. Knipe +9 more
TL;DR: It is found that the influenza virus-induced inflammatory milieu promoted internalization of S1PR1, which was pharmacologically inhibited with paroxetine, an inhibitor of GRK2, and genetic overexpression or administration of paroxete, days after influenza virus infection, was sufficient to reduce post-viral pulmonary fibrosis.
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Circulating biomarkers of endothelial dysfunction associate with ventilatory ratio and mortality in acute respiratory distress syndrome due to SARS-CoV-2 infection treated with anti-inflammatory therapies
Jehan Alladina,F. Giacona,Alexis Haring,Kathryn A. Hibbert,Benjamin D. Medoff,Eric P. Schmidt,Taylor Thompson,Bradley A. Maron,George A. Alba +8 more
- 01 Feb 2024
TL;DR: Biomarkers of inflammation, coagulation, and epithelial injury were not associated with clinical outcomes in a small cohort of patients with ARDS uniformly treated with immunomodulators, however, endothelial biomarkers, including plasma NEDD9, were associated with 60-day mortality.
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