Alexandre Perrier
9 Papers
Alexandre Perrier is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications.
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Papers
The extracellular domain of Her2 in serum as a biomarker of breast cancer.
TL;DR: The evidence that sHER2 ECD might be used in some situations as a biomarker for breast cancer is reviewed, finding it to be especially useful in metastatic disease for prognosis, as an indicator of cancer progression and of therapy response, particularly to anti-HER2 therapies.
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Prediction of Response to Immune Checkpoint Blockade in Patients with Metastatic Colorectal Cancer with Microsatellite Instability.
Toky Ratovomanana,Romain Nicolle,Romain Cohen,Abbie Diehl,Quentin Letourneur,Olivier Buhard,Alexandre Perrier,Erell Guillerm,Florence Coulet,P.F. Martínez Cervera,Patrick R. Benusiglio,Karim Labreche,Raphael Colle,Ada Collura,Emmanuelle Despras,Philippe Le Rouzic,Florence Renaud,Jérôme Cros,Agusti Alentorn,Mehdi Touat,Mira Ayadi,Pierre Bourgoin,Céline Prunier,Christophe Tournigand,Christelle De La Fouchardiere,David Tougeron,V. Jonchère,Jaafar Bennouna,Aurélien de Reyniès,Jean–François Flejou,Magali Svrcek,Thierry André,Alex Duval +32 more
TL;DR: In this article , the authors combined high-throughput DNA and RNA sequencing of tumors from 116 patients with MSI mCRC treated with anti-programmed cell death protein 1 ± anti-cytotoxic T-lymphocyte-associated protein 4 of the NIPICOL phase II trial (C1, NCT03350126, discovery set) and the ImmunoMSI prospective cohort (C2, validation set).
Non-invasive prenatal diagnosis of single gene disorders with enhanced relative haplotype dosage analysis for diagnostic implementation
Mathilde Pacault,C. Verebi,Magali Champion,Lucie Orhant,Alexandre Perrier,Emmanuelle Girodon,F. Leturcq,Dominique Vidaud,Claude Férec,Thierry Bienvenu,Romain Daveau,Juliette Nectoux +11 more
TL;DR: In this article , a universal and adaptable enhanced relative haplotype dosage (eRHDO) procedure was proposed for non-invasive prenatal diagnosis for single-gene disorders.
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Therapeutic strategies to overcome EGFR mutations as acquired resistance mechanism in ALK-rearranged non-small-cell lung cancer: Case Reports
Lionel Michaux,Alexandre Perrier,Camille Mehlman,Hussa Alshehhi,Antonin Dubois,Roger Lacave,Florence Coulet,Jacques Cadranel,Vincent Fallet +8 more
TL;DR: In this article , the authors presented two patients with EML4-ALK rearranged NSCLC, developing an acquired EGFR resistance mutation after receiving multiple lines of ALK TKIs.
Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data
Mélanie Eyries,Olivier Ariste,Gaelle Legrand,Noémie Basset,Erell Guillerm,Alexandre Perrier,C. Duros,Odile Cohen-Haguenauer,P. de la Grange,Florence Coulet +9 more
TL;DR: Retrospective analysis of targeted next-generation sequencing data from 359 patients was performed to detect the first report of a pathogenic MEI in PALB2, demonstrating that MEI analysis may help to improve molecular diagnostic yield and can be performed from targeted NGS data used for routine diagnosis.
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