Alexandre Louvet
French Institute of Health and Medical Research
143 Papers
697 Citations
Alexandre Louvet is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 37, co-authored 102 publications. Previous affiliations of Alexandre Louvet include university of lille.
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Papers
Early Liver Transplantation for Severe Alcoholic Hepatitis
Philippe Mathurin,Christophe Moreno,Didier Samuel,Jérôme Dumortier,Julia Salleron,François Durand,Hélène Castel,Alain Duhamel,Georges-Philippe Pageaux,Vincent Leroy,Sébastien Dharancy,Alexandre Louvet,Emmanuel Boleslawski,Valerio Lucidi,Thierry Gustot,Claire Francoz,Christian Letoublon,Denis Castaing,Jacques Belghiti,Vincent Donckier,François-René Pruvot,Jean-Charles Duclos-Vallée +21 more
TL;DR: Early liver transplantation can improve survival in patients with a first episode of severe alcoholic hepatitis not responding to medical therapy, and this benefit was maintained through 2 years of follow-up.
895
Alcoholic liver disease: mechanisms of injury and targeted treatment
TL;DR: This Review discusses the main pathways associated with the progression of liver disease, as well as potential therapeutic strategies targeting these pathways, and suggests that future clinical trials need to focus on end points other than mortality.
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Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients
Guillaume Lassailly,Robert Caiazzo,David Buob,Marie Pigeyre,Hélène Verkindt,Julien Labreuche,Violeta Raverdy,Emmanuelle Leteurtre,Sébastien Dharancy,Alexandre Louvet,Monique Romon,Alain Duhamel,François Pattou,Philippe Mathurin +13 more
TL;DR: Bariatric surgery induced the disappearance of NASH from nearly 85% of patients and reduced the pathologic features of the disease after 1 year of follow-up, suggesting it could be a therapeutic option for appropriate morbidly obese patients with NASH who do not respond to lifestyle modifications.
722
The Lille model: A new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids
Alexandre Louvet,Sylvie Naveau,Marcelle Abdelnour,M.-J. Ramond,Emmanuel Diaz,Laetitia Fartoux,Sébastien Dharancy,Frédéric Texier,Antoine Hollebecque,Lawrence Serfaty,Emmanuel Boleslawski,Pierre Deltenre,Valérie Canva,François-René Pruvot,Philippe Mathurin +14 more
TL;DR: In the largest cohort to date of patients with severe AH, it is demonstrated that the term “nonresponder” can now be extended to patients with a Lille score above 0.45, which corresponds to 40% of cases.
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Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
Yi Duan,Yi Duan,Cristina Llorente,Cristina Llorente,Sonja Lang,Katharina Brandl,Huikuan Chu,Lu Jiang,Lu Jiang,Richard C. White,Thomas H. Clarke,Kevin Nguyen,Manolito Torralba,Yan Shao,Jinyuan Liu,Adriana Hernandez-Morales,Lauren Lessor,Imran R Rahman,Yukiko Miyamoto,Melissa Ly,Bei Gao,Weizhong Sun,Roman Kiesel,Felix Hutmacher,Suhan Lee,Meritxell Ventura-Cots,Francisco Bosques-Padilla,Elizabeth C. Verna,Juan G. Abraldes,Robert S. Brown,Victor Vargas,José Altamirano,Juan Caballería,Debbie L. Shawcross,Samuel B. Ho,Samuel B. Ho,Alexandre Louvet,Michael R. Lucey,Philippe Mathurin,Guadalupe Garcia-Tsao,Ramon Bataller,Xin M. Tu,Lars Eckmann,Wilfred A. van der Donk,Ry Young,Trevor D. Lawley,Peter Stärkel,David T. Pride,Derrick E. Fouts,Bernd Schnabl,Bernd Schnabl +50 more
TL;DR: It is shown that bacteriophages can specifically target cytolytic E. faecalis, which provides a method for precisely editing the intestinal microbiota, and is linked with more severe clinical outcomes and increased mortality in patients with alcoholic hepatitis.